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CA2 — CAST
Text-mined interactions from Literome
Savart et al., Biochimie 1991
:
Leupeptin,
calpain inhibitor II, and the more selective calpain inhibitors calpeptin and MDL 28170 did not
block the activation of the purified PKC by
Ca2+ and phosphatidylserine
Kitahara et al., J Clin Endocrinol Metab 1986
(Adenoma...) :
The immunohistochemical distribution of
Ca2+ dependent cysteine proteinases ( calpains I and II ) and their endogenous inhibitor
calpastatin in normal and adenomatous human pituitary tissue was studied using specific antibodies
Kapprell et al., J Biol Chem 1989
:
Unautolyzed mu-calpain, however,
required slightly more
Ca2+ for half-maximal binding to
calpastatin than for half-maximal activity ... Binding of unautolyzed m-calpain and autolyzed mu-calpain to calpastatin occurred over a wide range of Ca2+ concentrations, and it seems likely that two or more
Ca2+ binding sites with different Ca2+ binding constants are
involved in binding of the calpains to
calpastatin
de Freitas et al., Neurochem Res 1996
:
Furthermore, exogenous
Ca2+/calmodulin induced increased in vitro phosphorylation of the cytoskeletal proteins and CaM-KII activity only in the
presence of
calpastatin , suggesting the presence of Ca ( 2+ ) -induced calpain mediated proteolysis