Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Savart et al., Biochimie 1991 : Leupeptin, calpain inhibitor II, and the more selective calpain inhibitors calpeptin and MDL 28170 did not block the activation of the purified PKC by Ca2+ and phosphatidylserine
Kitahara et al., J Clin Endocrinol Metab 1986 (Adenoma...) : The immunohistochemical distribution of Ca2+ dependent cysteine proteinases ( calpains I and II ) and their endogenous inhibitor calpastatin in normal and adenomatous human pituitary tissue was studied using specific antibodies
Kapprell et al., J Biol Chem 1989 : Unautolyzed mu-calpain, however, required slightly more Ca2+ for half-maximal binding to calpastatin than for half-maximal activity ... Binding of unautolyzed m-calpain and autolyzed mu-calpain to calpastatin occurred over a wide range of Ca2+ concentrations, and it seems likely that two or more Ca2+ binding sites with different Ca2+ binding constants are involved in binding of the calpains to calpastatin
de Freitas et al., Neurochem Res 1996 : Furthermore, exogenous Ca2+/calmodulin induced increased in vitro phosphorylation of the cytoskeletal proteins and CaM-KII activity only in the presence of calpastatin , suggesting the presence of Ca ( 2+ ) -induced calpain mediated proteolysis