Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — FOXO1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Essers et al., Science 2005 : beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells
Almeida et al., J Biol Chem 2007 : Moreover, we show that in osteoblastic cell models, oxidative stress ( exemplified by H ( 2 ) O ( 2 ) ) promotes the association of FoxOs with beta-catenin, beta-catenin is required for the stimulation of FoxO target genes by H ( 2 ) O ( 2 ), and H ( 2 ) O ( 2 ) promotes FoxO mediated transcription at the expense of Wnt-/T-cell factor mediated transcription and osteoblast differentiation
Hoogeboom et al., J Biol Chem 2008 : Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity ... beta-catenin , through binding, enhances FOXO transcriptional activity
Hoogeboom et al., Biochim Biophys Acta 2009 : A prominent feature of ROS induced FOXO activation is ROS induced binding of beta-catenin to FOXO [[6 ] M.A. Essers, L.M. de Vries-Smits, N. Barker, P.E. Polderman, B.M. Burgering, H.C. Korswagen, Functional interaction between beta-catenin and FOXO in oxidative stress signaling, Science ( New York, NY ) 308 ( 2005 ) 1181-1184, [ 7 ] M. Almeida, L. Han, M. Martin-Millan, C.A. O'Brien, S.C. Manolagas, Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription, J. Biol. Chem. 282 ( 2007 ) 27298-27305, [ 8 ] D. Hoogeboom, M.A. Essers, P.E. Polderman, E. Voets, L.M. Smits, B.M. Burgering, Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity, J. Biol. Chem. 283 ( 2008 ) 9224-9230 ]