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FOXO1 — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) (modification, activates)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer ) complex (STAT3) → FOXO1 (FOXO1) (modification, collaborate) Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer ) complex (STAT3) → STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) (modification, collaborate)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: FOXO1 (FOXO1) → STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) (modification, collaborate)
  Kortylewski et al., J Biol Chem 2003
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer ) complex (STAT3) → FOXO1 (FOXO1) (cell cycle arrest, activates) Nakajima et al., EMBO J 1996*
  Evidence: mutant phenotype
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) → GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) (transcription, activates)
  Kortylewski et al., J Biol Chem 2003, Wegenka et al., Mol Cell Biol 1993, Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1) → A2M (A2M) (transcription, activates) Kortylewski et al., J Biol Chem 2003, Wegenka et al., Mol Cell Biol 1993, Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Kortylewski et al., J Biol Chem 2003 : The effect of FKHR required the presence of functional STAT3 and was abrogated by the expression of dominant negative STAT3 mutants
Yang et al., J Biol Chem 2009 : Furthermore, FoxO1 binds to STAT3 and prevents STAT3 from interacting with the SP1.POMC promoter complex, and consequently, inhibits STAT3 mediated leptin action ... Furthermore, FoxO1 binds to STAT3 and prevents STAT3 from interacting with the SP1.POMC promoter complex, and consequently, inhibits STAT3 mediated leptin action
Oh et al., J Biol Chem 2011 : We further show that STAT3 binds directly to FoxO1 or FoxO3a promoter and that STAT3-deficiency resulted in down-regulation of the expression of FoxO1, FoxO3a and FoxO-target genes ( I?B and p27Kip1 )