UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to FOXO1

FOXO1 — YWHAH

Pathways - manually collected, often from reviews:

NCI Pathway Database FoxO family signaling: Ran/GTP/Exportin 1 complex (RAN-XPO1) → FOXO1/14-3-3 family complex (FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (translocation, activates)
Rena et al., EMBO J 2002
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Class I PI3K signaling events mediated by Akt: FOXO1-3a-4/14-3-3 family complex (FOXO3_FOXO4_FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, collaborate)
Brunet et al., Cell 1999, Kops et al., Nature 1999, Rena et al., J Biol Chem 1999, Brunet et al., J Cell Biol 2002
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Class I PI3K signaling events mediated by Akt: FOXO1-3a-4/14-3-3 family complex (FOXO3_FOXO4_FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) → FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1) (modification, collaborate)
Brunet et al., Cell 1999, Kops et al., Nature 1999, Rena et al., J Biol Chem 1999, Brunet et al., J Cell Biol 2002
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Class I PI3K signaling events mediated by Akt: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1) (modification, collaborate)
Brunet et al., Cell 1999, Kops et al., Nature 1999, Rena et al., J Biol Chem 1999, Brunet et al., J Cell Biol 2002
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database FoxO family signaling: FOXO1/14-3-3 family complex (FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) → FOXO1 (FOXO1) (modification, collaborate) Rena et al., Biochem J 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database FoxO family signaling: FOXO1/14-3-3 family complex (FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, collaborate)
Rena et al., Biochem J 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database FoxO family signaling: FOXO1 (FOXO1) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, collaborate)
Rena et al., Biochem J 2001
Evidence: mutant phenotype, physical interaction