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IFI44 — VEGFA

Text-mined interactions from Literome

Gupta et al., Exp Cell Res 1999 : VEGF activated the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 ( p44 mitogen activated protein kinase ; MAPK ) and ERK2 ( p42 MAPK ) in a time- and concentration dependent manner
Zhu et al., Cancer Lett 1999 : It effectively blocks VEGF-KDR interaction and inhibits VEGF stimulated activation of KDR and MAP kinases p44/p42 of human endothelial cells
Smith et al., Nat Med 1999 (Ischemia...) : IGF-1 receptor regulation of VEGF action is mediated at least in part through control of VEGF activation of p44/42 mitogen activated protein kinase, establishing a hierarchical relationship between IGF-1 and VEGF receptors
Pagès et al., Ann N Y Acad Sci 2000 (Neovascularization, Pathologic) : We demonstrated that p42/p44MAPKs stoichiometrically phosphorylate HIF-1 alpha in vitro and that HIF-1 dependent VEGF gene expression is strongly enhanced by the exclusive activation of p42/p44MAPKs
Berra et al., Biochem Pharmacol 2000 (Anoxia...) : We demonstrate that p42/p44 MAP kinases play a pivotal role in angiogenesis by exerting a determinant action at three levels : i ) persistent activation of p42/p44 MAP kinases abrogates apoptosis ; ii ) p42/p44 MAP kinase activity is critical for controlling proliferation and growth arrest of confluent endothelial cells ; and iii ) p42/p44 MAP kinases promote VEGF ( vascular endothelial growth factor ) expression by activating its transcription via recruitment of the AP-2/Sp1 ( activator protein-2 ) complex on the proximal region ( -88/-66 ) of the VEGF promoter and by direct phosphorylation of hypoxia-inducible factor 1 alpha ( HIF-1 alpha )
Tokuda et al., J Endocrinol 2001 : These results strongly suggest that p44/p42 MAP kinase activation is not involved in the PGE1 stimulated VEGF synthesis in osteoblasts but that p38 MAP kinase activation is involved
Bernatchez et al., Br J Pharmacol 2001 : 2. Using specific inhibitors and Western blot analysis, we herein report that in bovine aortic endothelial cells ( BAEC ), VEGF induces the synthesis of PAF through the cascade activation of Flk-1 receptor, phospholipase Cgamma ( PLCgamma ), protein kinase C ( PKC ) and p42/44 mitogen activated protein kinases ( MAPK )
Grazia Lampugnani et al., J Cell Biol 2003 : Comparing isogenic endothelial cells differing for vascular endothelial cadherin ( VE-cadherin ) expression only, we found that the presence of this protein attenuates VEGF induced VEGF receptor (VEGFR) 2 phosphorylation in tyrosine, p44/p42 MAP kinase phosphorylation, and cell proliferation
Miyanishi et al., J Bone Miner Res 2003 (MAP Kinase Signaling System...) : Exposure of monocyte/macrophages to titanium particles resulted in increased VEGF expression, p44/42 MAPK activation , and VEGF dependent macrophage chemotaxis
Favot et al., Thromb Haemost 2004 : The role of PDE2 and PDE4 in VEGF induced proliferation in HUVEC was investigated : 1 ) VEGF increased cAMP-hydrolytic activity by up-regulating the expression of PDE2 and PDE4 isozymes ; 2 ) VEGF increased progression in cell cycle with an increase in p42/p44 MAP kinase, cyclin A and cyclin D1 expressions and with a decrease in p21 waf1/cip1 and p27 kip1 expressions ; 3 ) EHNA ( 20 micro M ), a selective PDE2 inhibitor, RP73401 ( 10 micro M ), a selective PDE4 inhibitor blocked the VEGF induced increase in p42/p44 MAP kinase expression ; 4 ) RP73401, but not EHNA, blocked the VEGF induced increase in cyclin A and decrease in p27 kip1 expressions ; 5 ) EHNA, contrary to RP73401, enhanced the VEGF induced increase of cyclin A and decrease of p27 kip1
Balestrieri et al., Biochem Pharmacol 2006 (Sarcoma, Kaposi) : Western blot analysis revealed that Yuccaols reduced the VEGF induced phosphorylation of p38 and p42/44 , thus indicating a possible interference with the mechanism underlying the VEGF stimulated cell proliferation
Lee et al., Clin Cancer Res 2006 (Neoplasm Invasiveness...) : In OVCAR-3 and PC-3 cells, the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin/p70S6K and p42/p44 mitogen activated protein kinase pathways were required for LPA induced HIF-1alpha and VEGF expressions, whereas only the phosphoinositide 3-kinase/mammalian target of rapamycin/p70S6K pathway was important in SK-Hep1 cells
Kwon et al., Exp Dermatol 2007 : TAPS also suppressed VEGF induced phosphorylation of p42/44 extracellular signal regulated kinase and c-Jun N-terminal kinase
Xu et al., Neurol Res 2009 (Brain Neoplasms...) : Inhibiting hypoxia inducible factor-1alpha and p44/42 mitogen activated protein kinase pathways reduces the thrombin induced up-regulation of vascular endothelial growth factor
Hata et al., Graefes Arch Clin Exp Ophthalmol 2010 : The impact of simvastatin on VEGF induced phosphorylation of p44/42 mitogen activated protein (MAP) kinase, myosin light chain ( MLC ), and VEGF-receptor (VEGFR) 2 were examined by Western blotting