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BMP15 — CASP4

Text-mined interactions from Literome

Merino et al., Ann N Y Acad Sci 1999 : The BMP proapoptotic activity requires the expression of members of the msx family of closely related homeobox containing genes and is finally mediated by caspase activation, but the nature of the caspase ( s ) directly responsible for the cell death is also unknown
Haÿ et al., J Biol Chem 2001 : Consistent with these results, BMP-2 increases caspase-9 and caspase-3, -6, and -7 activity, and an anti-caspase-9 agent suppresses BMP-2 induced apoptosis
Mogi et al., J Biol Chem 2003 : Surprisingly, BMP-4 induced transient and potent activation of caspase-8 , caspase-2, and caspase-3, in this order
Haÿ et al., J Biol Chem 2004 : In contrast to SaOS2 cells, however, BMP-2 or BMP-2 overexpression did not increase caspase-9 and caspases-3, -6, and -7 activity and DNA fragmentation in OHS4 cells ... Consistently, BMP-2 increased protein kinase C ( PKC ) activity, and PKC inhibition suppressed BMP-2 induced caspase activity in SaOS2 but not in OHS4 cells that lack BMP-RIB ... A dominant negative BMP-RIB inhibited BMP-2 induced caspase activity, whereas wild-type BMP-RIB promoted caspase activity induced by BMP-2 in SaOS2 and MC3T3-E1 cells
Saito et al., Anticancer Res 2003 (Carcinoma, Squamous Cell) : The most cytotoxic BMP activated caspase-3 activity to the least extent, possibly in part due to the occurrence of necrosis
Lagna et al., Am J Physiol Lung Cell Mol Physiol 2006 (Hypertension, Pulmonary) : BMP dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells