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CASP4 — IFNG

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You et al., Mol Cell Biol 1999 : Furthermore, IFN-gamma induced a higher level of caspase 1 expression in Shp-2 ( -/- ) cells than in wild-type cells
Puren et al., Proc Natl Acad Sci U S A 1999 : In PBMCs, mature but not precursor IL-18 induces IFN-gamma ; in whole human blood stimulated with endotoxin, inhibition of caspase 1 reduces IFN-gamma production by an IL-1beta independent mechanism
Kano et al., Biochem Biophys Res Commun 1999 : Caspase-1 expression was little detected in hepatocytes, and constitutive and IFN-gamma induced mRNA expression of Fas or caspase-3 did not change in between wild type and IRF-1-deficient hepatocytes
Wright et al., J Biol Chem 1999 : In addition, IFN-gamma/TNF-alpha and IL-1alpha/IFN-gamma/TNF-alpha stimulate activation of caspase-8 and caspase-3 , which IL-13 pretreatment was able to partially inhibit and delay
Bergmann-Leitner et al., Cancer Immunol Immunother 2000 (Colonic Neoplasms) : IFNgamma also increased pro-caspase-3 protein expression and its subsequent activation in SW480 cells following Ag-specific CTL attack
Chen et al., J Biol Chem 2000 (Breast Neoplasms...) : Although LIGHT/IFN-gamma can activate caspase activity, neither benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone nor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone can completely inhibit LIGHT/IFN-gamma mediated apoptosis
O'Connell et al., J Cell Physiol 2000 : The extent of IFN-gamma mediated apoptosis sensitization in these two cell lines correlated well with the degree of IFN-gamma mediated upregulation of the proapoptotic protease caspase-1
Pirhonen et al., Eur J Immunol 2001 : Furthermore, IFN-alpha and IFN-gamma could induce caspase gene expression
Shin et al., Cancer Immunol Immunother 2001 (Carcinoma, Hepatocellular...) : IFN-gamma increased the mRNA expression of Fas, TRAIL and caspase-1 , and surface Fas was also increased
Suk et al., Immunol Lett 2001 : IFNgamma increased lipopolysaccharide (LPS) induced IL-18 production and caspase-1 expression, while PGE ( 2 ) inhibited LPS induced IL-18 production
Shin et al., Int J Cancer 2001 (Carcinoma, Hepatocellular...) : Among the 2 hepatitis B virus ( HBV ) -associated hepatoma cell lines, SNU-354 and SNU-368, IFN-gamma induced cell death and increased caspase-3 activity in SNU-368 but not in SNU-354
Létuvé et al., J Leukoc Biol 2001 (Hypereosinophilic Syndrome...) : Interleukin (IL)-5 and interferon (IFN)-gamma , two cytokines known to prolong eosinophil survival, inhibited Fas mediated apoptosis and caspase activation but poorly affected the decrease in DeltaPsi ( m )
Suk et al., J Neurochem 2002 (Glioma...) : Inflammatory activation ( lipopolysaccharide, interferon-gamma , and tumor necrosis factor-alpha treatment ) of rat astrocyte cultures and C6 glioma cells led to the induction of caspase-11 followed by activation of caspases-11, -1, and -3
Fulda et al., Oncogene 2002 (Neoplasms) : Importantly, IFNgamma induced caspase-8 expression also in cells with inactivation of the caspase-8 gene by hypermethylation, although no direct effect of IFNgamma on the methylation status of regulatory sequences of the caspase-8 gene was found ... Upregulation of caspase-8 and sensitization for apoptosis by IFNgamma was blocked by overexpression of dominant negative mutants of Stat1 or in Stat1-deficient U3A cells, while complementation of Stat1-deficient U3A cells with wild-type Stat1 restored the IFNgamma effect
Kumar et al., Cytokine 2002 : Interleukin-1F7B ( IL-1H4/IL-1F7 ) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
Chen et al., Int J Cancer 2002 (Glioma...) : Therefore, Kupffer cells execute their anti-tumor effect via increasing the production of NO, TNFalpha and IFNgamma and these cytotoxic molecules inhibit the growth of tumor by damaging cellular DNA and inducing apoptosis that was featured by downregulation of Bcl-2 but upregulation of caspase-8
Schönbeck et al., Am J Pathol 2002 (Aortic Aneurysm, Abdominal) : Notably, stenotic lesions, but not AAAs, contained mature forms of the interferon-gamma inducing cytokines IL-12 and IL-18 as well as the IL-18 processing enzyme caspase-1
Li et al., Am J Pathol 2002 : Interferon-gamma augments CD95 ( APO-1/Fas ) and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95 mediated apoptosis ... IFN-gamma also produces an increase in expression of pro-caspase-8 ( FLICE/MACH ) but does not significantly change expression of either Fas associated death domain (FADD) protein or cellular FLICE inhibitory protein ( cFLIP ), other proteins associated with the CD95 death inducing signaling complex ( DISC ) ... We conclude that IFN-gamma induces sensitivity of endothelium to CD95L mediated apoptosis, and that this response may result from increased expression of CD95 and/or pro-caspase-8
Chung et al., Blood 2003 : Interferon gamma (IFNgamma) acts on human erythroid colony forming cells ( ECFCs ) to up-regulate Fas, without a demonstrable change of Fas ligand (FasL) or Fas associated DD-containing protein ( FADD ) expression and activates caspase-8 plus caspase-3, which produce apoptosis ... Because the binding of FasL to Fas is the first step of the apoptosis cascade and IFNgamma strongly up-regulates Fas expression, we added FasL ( 50 ng/mL ) to the cultures with IFNgamma to accentuate the IFNgamma induced activation of caspase-8 and caspase-3 plus subsequent apoptosis ... SCF ( 100 ng/mL ) clearly inhibited the activation of caspase-8 and caspase-3 induced by IFNgamma and/or FasL, and it also reduced apoptosis as measured by the terminal dUTP nick-end labeling ( TUNEL ) assay
Dellacasagrande et al., J Immunol 2002 : IFN-gamma mediated caspase-3 activation and C. burnetii killing depend on the expression of membrane TNF ... In addition, anti-TNF Abs inhibited IFN-gamma mediated caspase-3 activation whereas soluble TNF had no effect on infected cells
Irawaty et al., Autoimmunity 2002 : TNF + IFNgamma did not induce caspase 3 activation in primary mouse islets
Yang et al., Cancer Res 2003 (Neuroblastoma) : Induction of caspase 8 by interferon gamma renders some neuroblastoma ( NB ) cells sensitive to tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB
Stuyt et al., Cytokine 2003 : Inhibition of caspase-1 reduced IFN-gamma and IL-1beta levels ( by 80 and 67 %, respectively ) when heat killed S. epidermidis was added to whole human blood cultures
Yang et al., Cancer Lett 2003 (Neuroblastoma) : Interferon (IFN)-gamma induces caspase 8 expression in most neuroblastoma cell lines regardless of the methylation status but fails to sensitize most NB to TRAIL ... Important questions remain unanswered : How does IFN-gamma induce caspase 8 and why is the induction heterogeneous ?
Kalai et al., J Cell Biol 2003 (Inflammation...) : In fibroblasts and B16/B16 melanoma cells, caspase-12 expression is stimulated by IFN-gamma but not by IFN-alpha or -beta
Kawai et al., Mol Cell Biol 2003 : Conversely, small interfering RNA mediated reduction of ZIPK, Daxx, or Par-4 expression decreased activation of caspase and apoptosis induced by As ( 2 ) O ( 3 ) and IFN-gamma
Zhou et al., J Biol Chem 2003 : Activation of caspase 8 by IFNgamma did not result in increased apoptosis
Liu et al., Cytokine 2003 : Effect of IFNgamma on caspase-3 , Bcl-2 and Bax expression, and apoptosis in rabbit placenta
Ruiz-Ruiz et al., J Biol Chem 2004 (Breast Neoplasms) : The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1 ... Our findings show that IFN-gamma induces the up-regulation of caspase-8 mRNA expression through a protein synthesis dependent mechanism involving the action of the IFN-gamma-inducible transcription factor interferon regulatory factor-1 (IRF-1) and without altering mRNA stability
Kim et al., J Pediatr Surg 2004 (Neuroblastoma) : Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter ... The authors found that interferon-gamma induces caspase-8 expression in neuroblastoma cells irrespective of the gene silenced by hypermethylation of caspase-8 promoter
Choi et al., J Neurooncol 2004 (Astrocytoma) : Interestingly, caspase-1 protein expression but not that of caspase-3 nor -8 was up-regulated by IFN-gamma only in Fas-sensitive CRT-J cells but not in Fas-resistant U373-MG cells
Klampfer et al., J Biol Chem 2004 (Inflammation) : In contrast, silencing of STAT1 did not interfere with IFNgamma induced expression of STAT2 and caspase-7 , and HDAC inhibitors did not preclude IFNgamma induced expression of STAT1, STAT2, and caspase-7, suggesting that HDAC inhibitors impede the expression of IFNgamma target genes whose expression depends on STAT1 but do not interfere with STAT1 independent signaling by IFNgamma
Höpfner et al., BMC cancer 2004 (Gastrointestinal Neoplasms...) : Above 10 U/ml IFNgamma induced apoptosis-specific caspase-3 activity in a time dependent manner in either cell line and caused a dose dependent arrest in the S-phase of the cell cycle
Buntinx et al., J Neurosci Res 2004 : Some of these genes are specifically up-regulated by cytokine treatment ; e.g., caspase-1 is up-regulated by IFN-gamma
Inaba et al., Pediatr Blood Cancer 2004 (Osteosarcoma) : Western blotting analysis also revealed that IFN-gamma caused up-regulation of caspase-8 in all cell lines, but no change in Fas associated death domain protein ( FADD/MORT1 ) or caspase-3
Chang et al., J Cell Biochem 2004 : Besides, LIGHT/IFN-gamma could not activate caspase-3 and -9, but decreased mitochondrial membrane potential
Johnsen et al., Int J Oncol 2004 (Neuroblastoma) : Inhibitors of DNA methyltransferases and IFN-gamma induce expression of caspase-8 , and sensitise some neuroblastoma cells to TRAIL mediated apoptosis ... In five of the neuroblastoma cell lines ( SHEP-1, SK-N-AS, SK-N-FI, SH-SY-5Y and Kelly ), IFN-gamma promoted TRAIL mediated cleavage of caspase-8 , initiating a caspase cascade involving caspase-7 and PARP followed by apoptosis ... In three of the cell lines [ SK-N-BE ( 2 ), SK-N-DZ and IMR-32 ] caspase-8 expression was induced by IFN-gamma , but the cells were still resistant to TRAIL mediated apoptosis
Tang et al., FEBS Lett 2005 (Neoplasms) : In this study, we use substrate cleavage assays to systematically investigate RC-RNase- and RC-RNase/IFN-gamma induced caspase activation in HL-60, MCF-7, and SK-Hep-1 cells ... We find that RC-RNase and RC-RNase/IFN-gamma induce mitochondria mediated caspase activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells, although death of SK-Hep-1 cells is closely related to mitochondrial disruptions
Du et al., Kidney Int 2005 : Both IL-2 and IFN-gamma induced TEC apoptosis and activated caspase-8
Awasthi et al., Invest Ophthalmol Vis Sci 2005 : MG132 prevented the IFN-gamma induced increase in caspase-1 , -6, and -8 activities
Tekautz et al., Biochim Biophys Acta 2006 (Neuroblastoma) : Interferon-gamma (IFN-gamma) induces caspase-8 in NB cells, sensitizing them to death receptor mediated apoptosis
De Ambrosis et al., Int J Cancer 2007 (Neuroblastoma) : In these last cells, up-regulation of caspase-8 by IFN-gamma was associated to induction of IRF-1 and IRF-2 binding to caspase-8 promoter and increased histone acetylation
Kulkarni et al., Apoptosis 2006 : TNF-alpha and IFN-gamma induced apoptosis in HSG cells and resulted in the activation of caspase 8 and the `` death receptor '' pathway
Scheller et al., J Neural Transm Suppl 2006 : In previous studies we have reported that caspase inhibitors induce expression of various proinflammatory cytokines in CD95 stimulated primary T cells, such as TNF-alpha, IFN-gamma and GM-CSF
Stang et al., Oncogene 2007 (Breast Neoplasms) : Here we demonstrate that in MDA468 breast cancer cells, apoptosis by IFN-gamma is mediated by IRF-1 and IFN-gamma , and IRF-1 induced apoptosis is caspase mediated
Lissat et al., Am J Pathol 2007 (Bone Neoplasms...) : Interferon-gamma induces expression of caspase-8 at concentrations achievable in humans and sensitizes cells to TRAIL ... Here, we report on the status of caspase-8 expression in tumors from patients with Ewing 's sarcoma, the effect of interferon-gamma on caspase-8 expression and apoptosis, and the role of caspase-8 for TRAIL- and chemotherapy mediated apoptosis in Ewing 's sarcoma
Meister et al., Eur J Cancer 2007 (Cerebellar Neoplasms...) : Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy ... In this study, IFN-gamma mediated up-regulation of caspase-8 in human MB cells was found to result in chemosensitization to cisplatin, doxorubicin and etoposide, and sensitisation to radiation
Holohan et al., J Cell Mol Med 2008 (Insulinoma) : The broad range caspase inhibitor, Boc-D-fmk, blocked IL-1beta/IFNgamma -induced caspase activity, but not nitric oxide production nor cell death
Das et al., Neurochem Res 2009 (Glioblastoma...) : Also, IFN-gamma activated caspase-8 and cleaved Bid to truncated Bid ( tBid ) for translocation to mitochondria
Souza et al., J Endocrinol 2008 : In contrast, IFNgamma had no effect on caspase-3 activity
Eley et al., Am J Physiol Endocrinol Metab 2008 (Muscular Atrophy) : These results suggest that TNF-alpha/IFN-gamma and ANG II induce muscle protein degradation by a common signaling pathway, which is attenuated by HMB, and that this involves the initial activation of caspase-3 and -8 , followed by autophosphorylation and activation of PKR, which then leads to increased ROS formation via activation of p38 MAPK
Breitbach et al., Infect Immun 2009 (Melioidosis) : Moreover, caspase-1 dependent IFN-gamma production is likely to contribute to resistance in murine melioidosis
Solarewicz-Madejek et al., Clin Exp Allergy 2009 (Asthma...) : The intracellular caspase-3 activation in SMC was significantly increased by IFN-gamma , sFasL, TRAIL, Th1 and Th2 cell supernatants
Häcker et al., Oncogene 2009 (Cerebellar Neoplasms...) : It is important to note that VA and IFN-gamma restore caspase-8 expression and sensitivity to TRAIL in primary medulloblastoma samples and significantly potentiate TRAIL mediated suppression of medulloblastoma growth in vivo
Cho et al., Arch Pharm Res 2010 : Moreover, we found that IFN-gamma increases caspase-3 activity that had been induced by serum/amino acid depletion, and that JAK1 signaling is involved in capase-3 activation and in the enhancement of apoptosis by IFN-gamma
Mailankot et al., Int J Biochem Cell Biol 2010 : The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content
Burova et al., Tsitologiia 2010 : Further, it was demonstrated that IFNgamma induced the caspase 3 activation in A431 cells, suggesting an involvement of active caspase 3 in IFNgamma induced apoptosis
Ghayur et al., Nature 1997 : A selective caspase-1 inhibitor blocks both lipopolysaccharide induced IL-1beta and IFN-gamma production from human mononuclear cells
Chin et al., Mol Cell Biol 1997 : We further demonstrated that both EGF and IFN-gamma induced caspase 1 ( interleukin-1beta converting enzyme [ ICE ] ) gene expression in a STAT dependent manner