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CASP4 — MAPK3

Text-mined interactions from Literome

Biard-Piechaczyk et al., Virology 2000 (Cell Transformation, Viral) : This cell death program was insensitive to pertussis toxin and did not involve activation of the stress- and apoptosis related MAP kinases p38 ( MAPK ) and SAPK/JNK but was inhibited by a broad spectrum caspase inhibitor ( z-VAD.fmk ) and a relatively selective inhibitor of caspase 3 ( z-DEVD.fmk )
Galán et al., J Biol Chem 2000 (Necrosis) : In a similar manner, p38 ( MAPK ) phosphorylation was not affected by the caspase inhibitors Z-VAD and DEVD-CHO, which nevertheless prevented apoptosis
Zhuang et al., J Biol Chem 2000 : p38 mitogen activated protein kinase is activated and involved in cleavage of caspase-3 during apoptosis induced by a number of stimuli
Mukherjee et al., J Neurochem 2001 : Complement anaphylatoxin C5a neuroprotects through mitogen activated protein kinase dependent inhibition of caspase 3
Varghese et al., J Immunol 2001 : Thus, inhibition of p38 MAPK resulted in the activation of caspase 9 and cleavage of the adaptor molecule BH3 interacting domain death agonist, and blocked NF-kappaB mediated transactivation, without affecting the nuclear translocation of NF-kappaB
Yu et al., Cancer Res 2002 (MAP Kinase Signaling System) : Synergistic potentiation of STI571 mediated lethality by PD184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways, including caspase dependent down-regulation of Bcr-Abl and Bcl-2 ; caspase independent down-regulation of Bcl-x ( L ) and Mcl-1 ; activation of JNK, p38 MAPK , and p34 ( cdc2 ) ; and diminished phosphorylation of Stat5 and CREB
Stefanelli et al., FEBS Lett 2002 : The inhibitor of ERK activation PD98059 abolished caspase activation, but caspase inhibition did not reduce ERK 1/2 phosphorylation, suggesting that ERK activation is placed upstream of caspases
Tadlock et al., Am J Physiol Gastrointest Liver Physiol 2003 (Bile Duct Neoplasms) : Inhibition of p38 MAPK with SB-203580 increased basal caspase activity
Sarker et al., J Neurochem 2003 (Pheochromocytoma) : The caspase inhibitor, zVAD, and the mitochondrial pore opening inhibitor, cyclosporine A, blocked anandamide induced cell death but not p38 MAPK/JNK activation, suggesting that activation of these kinases may occur upstream of mitochondrial associated events
Lüschen et al., Exp Cell Res 2004 : In consequence, we found that inhibition of p38 MAPK led to the activation of the executioner caspase-3
Alvarado-Kristensson et al., J Exp Med 2004 (Inflammation) : Consequently, p38-MAPK can directly phosphorylate and inhibit the activities of caspase-8 and caspase-3 and thereby hinder neutrophil apoptosis, and, in so doing, regulate the inflammatory response
Marchetti et al., Cell Death Differ 2004 : p53 can inhibit cell proliferation through caspase mediated cleavage of ERK2/MAPK
Russo et al., Endocrinology 2004 (Neuroblastoma) : Leptin 's antiapoptotic activity required Janus kinase/STAT, MAPK , and phosphatidylinositol-3-kinase activation because the antiapoptotic effects of leptin were abolished, and caspase-3 immunoreactivity increased in the presence of the specific blockers AG490, U0126, or LY294002
Fiala et al., Cardiovasc Toxicol 2004 (Cardiomyopathies...) : HIV-1, gp120, or Tat induced Erk 1/2 phosphorylation, activation of caspase-3 , and apoptosis of NRVMs and CAECs ; all of these were inhibited by a MAPK/ERK-kinase (MEK) inhibitor U0126
Dong et al., Wound Repair Regen 2004 (Hyperglycemia) : After this treatment, cell proliferation, activation of mitogen activated protein kinase ( MAPK ), the level of apoptosis, and caspase-3 activation induced by removal of growth factors or tumor necrosis factor-alpha treatment were studied
Tuo et al., Life Sci 2004 (MAP Kinase Signaling System) : The opposing effects of onychin on phosphorylation levels of p38MAPK and ERK1/2, and its caspase-3 inhibition might play a role in the beneficial effect of onychin on endothelial injury
Alvarado-Kristensson et al., J Biol Chem 2005 : Consequently, the early and temporary activation of PP2A in neutrophils impaired not only the p38 MAPK mediated inhibition of caspase 3 but also restored the activity to caspase 3 that had already been phosphorylated and thereby inactivated
Xifro et al., Eur J Neurosci 2005 : By contrast, K25 mediated neuroprotection was BDNF independent and was mediated by a mitogen activated protein kinase- and PI3-kinase dependent inhibition of caspase-3
Hou et al., Ann N Y Acad Sci 2005 : In conclusion, sesamolin protects microglia against H2O2 induced cell injury and this protective effect was accompanied by its inhibition of p38 MAPK and caspase-3 activation and ROS production
Dejda et al., Pharmacol Rep 2005 (Neurodegenerative Diseases) : The mechanism underlying neuroprotective properties of PACAP seems to involve activation of adenylyl cyclase ( AC ) -- > cyclic adenosine 3',5'-mono-phosphate ( cAMP ) -- > protein kinase A (PKA) and mitogen activated protein ( MAP ) kinase pathways, and inhibition of caspase-3
Okada et al., Am J Physiol Heart Circ Physiol 2005 (Reperfusion Injury) : The p38 MAPK inhibitor SB-203580 abrogated activation of p38 MAPK, translocation of HSP27, and F-actin reorganization and prevented cytochrome c release, caspase-3 activation, and DNA fragmentation
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11 ... However, it is unknown whether p38 MAPK mediates the following important events in both myocardial apoptosis and functional depression : mitogen activated protein kinase activated protein kinase 2, caspase-1 , caspase-3, and caspase-11 activation, and tumor necrosis factor, interleukin-1beta and interleukin-6 production ... The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression : mitogen activated protein kinase activated protein kinase 2, caspase-1 , caspase-3 and caspase-11 activation, and tumor necrosis factor, interleukin-1beta, interleukin-6 production after myocardial ischemia
Yang et al., Food Chem Toxicol 2006 : Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation
Wang et al., J Mol Cell Cardiol 2006 (Inflammation...) : Following reperfusion, homogenized hearts were analyzed for TNF-alpha, IL-1beta, and IL-6 gene and protein expression, p38 MAPK activation , and the apoptosis related proteins caspase-3 and Bcl-2
Cagnol et al., Apoptosis 2006 : These findings reveal that prolonged ERK/MAPK stimulation results in caspase 8 activation and cell death
Pladzyk et al., Exp Eye Res 2006 : AR over-expression also prevented the lipid aldehyde induced activation of caspase-3 , MAPK , JNK and the expression of Bcl-2 family of proteins in HLEC
De Chiara et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Both cytochrome c release and caspase activation triggered by p38 MAPK activation and Bcl-2 phosphorylation are absent in embryonic fibroblasts from p38alpha knock-out mice ( p38alpha ( -/- ) MEF ), whereas they occur within 12 h of serum withdrawal in p38alpha ( +/+ ) MEF ; moreover, they can be prevented by p38 MAPK inhibitors and are not associated with the synthesis of the proapoptotic proteins Bax and Fas
Johnson et al., Anticancer Res 2006 (Neoplasms) : Calcitriol induces G0/G1 arrest, modulates p27 and p21, the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest, and induces cleavage of caspase 3, PARP and the mitogen activated protein kinase ( MEK ) in a caspase dependent manner
Raymond et al., Endocrinology 2006 (Leiomyoma...) : A pharmacological approach showed that the effect of ET-1 on caspase-3/7 activation in ELT3 cells was not dependent on phosphatidylinositol 3-kinase, ERK1/2 , or phospholipase D activities
Xu et al., Atherosclerosis 2007 : Inhibitors of the Akt, ERK1/2 , Src kinase and transfection with a dominant negative Akt cDNA blocked the inhibitory effect of cyanidin on cleaved caspase-3
Wang et al., Apoptosis 2007 (MAP Kinase Signaling System) : Inhibition of ERK1/2 with PD98059 caused further enhancement in apoptosis and caspase-3 and 9 activity, while a selective p38 MAPK inhibitor, SB203580 and JNK inhibitor, SP600125 significantly inhibited E. coli induced apoptosis and caspase-3 and 9 activity in U937 cells
Hsu et al., Toxicology 2007 (Osteosarcoma) : This p38 MAPK phosphorylation subsequently activated caspase-3 leading to apoptosis
Ou et al., Eur J Pharmacol 2007 (Carcinoma, Renal Cell...) : Selective inhibitors of ERK, p38 MAPK , and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin induced cytotoxicity and reduced increased caspase activity
El Mchichi et al., Cell Death Differ 2007 : p38 MAPK and MSK1 mediate caspase-8 activation in manganese induced mitochondria dependent cell death
Kwon et al., Life Sci 2007 : IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor
Myatt et al., Oncogene 2008 (Sarcoma, Ewing) : Furthermore, inhibition of p38 ( MAPK ) activity and knockdown of EWS-Fli1 reduced fenretinide induced mitochondrial permeabilization, cytochrome c release, caspase and PARP cleavage, consistent with the hypothesis that p38 ( MAPK ) is critical for activation of the death cascade by fenretinide in ESFT cells
Kawahara et al., Invest Ophthalmol Vis Sci 2007 : Furthermore, ICG, but not BBG, induced the cleavage of caspase-9 and caspase-3, which was inhibited by an inhibitor of p38 MAPK
Niswander et al., Brain Res 2007 : Hyperosmotic stress induced caspase-3 activation is mediated by p38 MAPK in the hippocampus
Kim et al., Cancer Lett 2008 (Leukemia, Promyelocytic, Acute) : Pharmacological inhibition of p38 MAPK with SB203580 or expression of a dominant negative p38 MAPK attenuated DNA fragmentation, caspase-3 activation, and Bax translocation in response to ceramide
Belyanskaya et al., Lung Cancer 2008 (Carcinoma, Small Cell...) : TRAIL induced SCLC cell proliferation was mediated by extracellular signal regulated kinase 1 and 2, and dependent on the expression of surface TRAIL-receptor 2 (TRAIL-R2) and lack of caspase-8 , which is frequent in SCLC
Gomes et al., Neurosci Lett 2008 (Neuroblastoma) : However, p38 MAPK inhibition attenuated caspase-3 cleavage in SU1498/SB202190 treated cells, indicating that p38 MAPK and caspase-3 only contributed in part to the total levels of caspase-3/7 induced by VEGFR2 inhibition
Kim et al., Anticancer Res 2007 (Prostatic Neoplasms) : EGCG+ibuprofen induced MAPK activation, caspase activation and the inhibition of Bfl-1 expression, all of which were blocked by the antioxidant, N-acetyl-L-cysteine (NAC)
Lee et al., J Biol Chem 2008 (Disease Models, Animal...) : Furthermore, overexpression of PRX1 protected cells against 6-OHDA induced activation of p38 MAPK and subsequent activation of caspase-3
Zhou et al., Toxicol Appl Pharmacol 2008 : Knockdown of JWA attenuated arsenic trioxide induced apoptosis, and was accompanied by significantly reduced activity of caspase-9 , enhanced Bad phosphorylation and inhibited MEK1/2, ERK1/2 and JNK phosphorylations
Moosavi et al., Toxicol Appl Pharmacol 2008 : The occurrence of apoptosis in these cells were accompanied with caspase-8 mediated p21 cleavage and delayed activation ( 24 h ) of JNK1/2 and p38 MAPK
Wang et al., Biomed Pharmacother 2009 : P38MAPK regulates caspase-3 by binding to caspase-3 in nucleus of human hepatoma Bel-7402 cells during anti-Fas antibody- and actinomycin D-induced apoptosis
Park et al., Mol Cancer Ther 2008 (Carcinoma, Hepatocellular...) : In parallel, treatment of cells with MEK1/2 inhibitors and 17AAG caused a p38 MAPK dependent association of caspase-8 with CD95
Lu et al., Clin Exp Pharmacol Physiol 2009 (Osteosarcoma) : Desipramine induced Ca-independent apoptosis in Mg63 human osteosarcoma cells : dependence on P38 mitogen activated protein kinase regulated activation of caspase 3 ... Desipramine induced caspase 3 activation required p38 MAPK activation
Krieg et al., Mol Immunol 2009 : As revealed by gene transfer experiments, these structural changes in RIP2-beta are associated with a loss of activation with respect to NF-kappaB and MAPK activation , IL-1beta secretion, and caspase-8 mediated apoptosis
Zhao et al., Int J Cardiol 2010 (MAP Kinase Signaling System) : Second, we found that activity of p38-MAPK ( mitogen activated protein kinase ) and caspase-3 was elevated in the cells treated with PAF, without altering activity of ERK and JNK, and that PAF induced enhancement of caspase-3 activity was attenuated by application of either BAPTA/AM or SB203580 ( p38 inhibitor )
Suri et al., Biomaterials 2009 (Adenocarcinoma...) : RGDSK/K-RNTs ( 1 : 10-40 : 400 microM ) also caused a concentration- and P38 MAPK dependent increase in caspase-3 activity and DNA fragmentation in Calu-3 cells at 18 h of exposure
Yoon et al., Mol Cancer Res 2009 (MAP Kinase Signaling System) : Activation of p38 mitogen activated protein kinase is required for death receptor independent caspase-8 activation and cell death in response to sphingosine ... Inhibition of p38 MAPK led to the marked suppression of death receptor independent caspase-8 activation and subsequent cell death induced by sphingosine ... In this study, we show that sphingosine induces death receptor independent caspase-8 activation and apoptotic cell death via p38 mitogen activated protein kinase ( MAPK ) activation and that suppression of the MAPK/extracellular signal regulated kinase ( ERK ) kinase/ERK pathway by protein phosphatase 2A (PP2A) is required for p38 MAPK activation
Kim et al., Bone 2009 (Bone Resorption) : Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK
Lee et al., J Ethnopharmacol 2009 (MAP Kinase Signaling System) : Taken together, these findings strongly demonstrate that hexane fraction of Solanum lyratum herba exerts antitumor activity via caspase activation and MAPK regulation and can be effectively applied to lung cancer as a cancer chemopreventive agent
Chen et al., J Neurochem 2009 (MAP Kinase Signaling System) : Simultaneous inhibition of PKCalpha and beta and MAPK abolished VP-induced Bad phosphorylation, but it only partially prevented caspase 3 inhibition
Lin et al., Mol Immunol 2009 (Arthritis, Rheumatoid) : Suppression of p38 MAPK sensitized T cells to Fas mediated apoptosis and increased caspase-8 and caspase-3 cleavage
Li et al., Plant Signal Behav 2008 : We recently showed that a mitogen activated protein kinase ( MAPK ) is involved in loss of pollen viability, stimulation of caspase-3-like ( DEVDase ) activity and later DNA fragmentation in incompatible pollen
Asur et al., Mutat Res 2010 (MAP Kinase Signaling System) : The focus of the current study was to determine the involvement of the MAPK proteins in bystander effects induced by physical and chemical DNA damaging agents and to evaluate the effects of MAPK inhibition on bystander induced caspase 3/7 activation ... We also evaluated the effect of MAPK inhibition on bystander induced caspase 3/7 activity to determine the role of MAPK proteins in bystander induced apoptosis
Yadav et al., Free Radic Biol Med 2010 : Benfotiamine prevented LPS induced apoptosis, expression of the Bcl-2 family of proapoptotic proteins, caspase-3 activation , and PARP cleavage and altered mitochondrial membrane potential and release of cytochrome c and apoptosis inducing factor and phosphorylation and subsequent activation of p38-MAPK , stress activated kinases ( SAPK/JNK ), protein kinase C, and cytoplasmic phospholipase A2 in RAW cells
Xie et al., Neuropharmacology 2010 : In addition, inhibition of p38 MAPK by its specific inhibitor SB203580 significantly inhibited morphine induced apoptosis and caspase-3 activation
Tsuda et al., BMC neuroscience 2011 (Sciatic Neuropathy) : In the present study, axonal outgrowth, activation of ERK1/2 by phosphorylation ( p-ERK 1/2 ) and immunoreactivity of cleaved caspase 3 were examined after immediate, delayed, or no repair of transected rat sciatic nerves
Jabbour et al., Transplantation 2011 (Myocardial Reperfusion Injury) : Functional improvements were accompanied by increased phosphorylation of Akt, ERK1/2 , STAT3, and GSK-3ß and reduced cleaved caspase-3 ( P < 0.01 )
Feng et al., Indian J Exp Biol 2011 : Inhibition of p38MAPK also significantly attenuates caspase-3 and bax protein expressions, but increased significantly bcl-2 expression as determined by Western blot analysis
Brereton et al., J Immunol 2011 : LT enhanced IL-23 and IL-1a production from DCs via activation of ERK MAPK and IL-1ß secretion through activation of caspase-1 and the NLRP3 inflammasome
Hedl et al., J Biol Chem 2011 : Moreover, caspase-1 inhibition significantly attenuates MDP mediated early MAPK activation
Jantas et al., Neurotoxicology 2011 : The obtained data provided evidence for neuroprotective potency of MAPK/ERK1/2 and calpain, but not caspase-3 inhibition against the neurotoxic effects of LC in primary cortical neurons and give rationale for using these inhibitors in the treatment of neurodegenerative diseases connected with proteasome dysfunction
Brama et al., J Endocrinol Invest 2012 (MAP Kinase Signaling System...) : In contrast, caspase inhibitors did not reduce the cadmium induced MAPK phosphorylation, suggesting an independent activation of these pathways ... In conclusion, at least 2 pathways appear activated by cadmium in osteoblasts : a direct induction of caspase-8 followed by activation of caspase-3 and an indirect induction by phosphorylation of ERK1/2, p38, and JNK MAPK triggering activation of caspase-8 and -3
Wasik et al., Cell death & disease 2011 (Lymphoma, Mantle-Cell) : Agonists to CB1 and CB2 promote ceramide de novo synthesis, p38-mitogen activated protein kinase dependent activation of caspase-3 and apoptotic cell death in most MCLs
Liu et al., Free Radic Biol Med 2012 (MAP Kinase Signaling System) : It also reduced the Bax/Bcl-2 ratio, the release of cytochrome c, the activation of caspase-3 , and the phosphorylation of p38 MAPK in a concentration dependent manner
Slawinska-Brych et al., Leuk Res 2013 (Multiple Myeloma) : The combination of simvastatin and thalidomide augmented caspase 8 and 3 activation , and the additional application of p38 MAPK inhibitor resulted in enhanced apoptosis of MM cells concomitant with increased caspase 9 and 3 activation, as well as JNK phosphorylation
Wang et al., Arch Pharm Res 2013 : Furthermore, PD98059 ( ERK1/2 inhibitor ) significantly enhanced 2-hydroxy-3-methylanthraquinone induced apoptosis in U937 cells, whereas caspase-3 inhibitor or SB203580 ( p-p38MAPK inhibitor ), decreased apoptosis in U937 cells
Hollborn et al., PloS one 2013 : The cytotoxic effect of curcumin involved activation of caspase-3 and calpain, intracellular calcium signaling, mitochondrial permeability, oxidative stress, increased phosphorylation of p38 MAPK and decreased phosphorylation of Akt protein
Bai et al., Int J Biochem Cell Biol 2013 : The disruption of mitochondrial outer membrane permeabilisation, the activation of caspase-3/7 and 9, the downregulation of Bcl-2, the upregulation of Bax, and the activation of p38 MAPK , ERK and NF-?B were all observed in HIV-1 Tat treated RPE cells