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IL10 — TLR10

Text-mined interactions from Literome

Netea et al., Trends Microbiol 2004 (Bacterial Infections...) : Three major TLR mediated escape mechanisms have been identified : TLR2 induced immunosuppression, especially through induction of interleukin (IL)-10 release ; blockade of TLR recognition ; and TLR mediated induction of viral replication
Reithmeier-Rost et al., Cell Immunol 2004 (Yersinia Infections) : Moreover, the involvement of IL-10 in TLR tolerance induction seems to be a more general phenomenon as shown by experiments using different TLR-agonists in IL-10 ( -/- ) macrophages
Maloney et al., J Biol Chem 2005 (MAP Kinase Signaling System) : A52R mediated enhancement of TLR induced IL-10 may be important to virulence, given the role of IL-10 in immunoregulation
Boyd et al., J Immunol 2005 : The wild-type acylated toxin ( A-CyaA ) and nonacylated CyaA ( NA-CyaA ), but not CyaA with an inactive adenylate cyclase domain ( iAC-CyaA ), enhanced TLR-ligand induced IL-10 and inhibited IL-12, TNF-alpha, and CCL3 production by macrophages and DC
Martin et al., Nat Immunol 2005 (Inflammation...) : Stimulation of monocytes or peripheral blood mononuclear cells with TLR2, TLR4, TLR5 or TLR9 agonists induced substantial increases in interleukin 10 production while suppressing the release of proinflammatory cytokines after GSK3 inhibition
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2 ... Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12, and IL-10 production, which is observed in control DC with intact NOD2
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : In response to TLR signals, MKP-1-deficient macrophages produced 5- to 10-fold higher IL-10 , which could be blocked by a p38 MAPK inhibitor
Agrawal et al., J Immunol 2006 (Encephalomyelitis, Autoimmune, Experimental...) : Consistent with this observation, dendritic cells from ERK1 ( -/- ) mice show enhanced IL-12p70 and reduced IL-10 secretion in response to TLR stimulation
Bekeredjian-Ding et al., J Immunol 2006 : Furthermore, TLR8 ligation inhibited LPS induced IL-10 in monocytes, and LPS alone gained the ability to stimulate IL-12p70 in monocytes when the IL-10 receptor was blocked
Schmidt et al., J Immunol 2006 : Bruton 's tyrosine kinase is required for TLR induced IL-10 production ... We demonstrate that Btk is activated by TLR4 in primary macrophages and is required for normal TLR induced IL-10 production in multiple macrophage populations
Boonstra et al., J Immunol 2006 : Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF dependent TLR signals, and TLR independent signals
Weaver et al., J Leukoc Biol 2007 : It is notable that exogenous recombinant IFN-gamma ( rIFN-gamma ) suppresses cell-surface, TLR mediated IL-10 production as well as CD163 up-regulation
Samarasinghe et al., J Interferon Cytokine Res 2006 (Inflammation) : TLR stimulated IL-10 production may regulate DC maturation steps, thereby influencing the ensuing immune responses
Li et al., J Immunol 2007 : However, TLR induced production of IL-10 was increased and that of IFN-gamma-inducible protein decreased by Alum cotreatment
Polumuri et al., J Immunol 2007 : Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophages ... This increase was blocked by PI3K inhibitors, wortmannin or LY294002, as was the effect of FcgammaR ligation on TLR induced IL-12 and IL-10
Harzenetter et al., J Immunol 2007 (Endotoxemia) : Inhibition of TLR responses was independent of IL-10 and did not involve perturbation of canonical TLR signaling, including activation of MAPK and NF-kappaB
Ferwerda et al., J Leukoc Biol 2007 (Crohn Disease) : TLR induced TNF-alpha, IL-1beta, and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10 , IL-12 and IFN-gamma by B cells
Vicente-Suarez et al., Eur J Immunol 2007 (Inflammation) : Several studies have linked the activation of extracellular signal regulated kinases with IL-10 induction by TLR
Allam et al., J Allergy Clin Immunol 2008 : Furthermore, TLR4 ligation on oLCs increased their release of the anti-inflammatory cytokine IL-10 and decreased their stimulatory capacity toward T cells ... Moreover, TLR4-ligation on oLCs induced IL-10 , TGF-beta1, Forkhead box protein 3, IFN-gamma, and IL-2 production in T cells
Nakano et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid...) : Moreover, TLR9-CpG interaction enhanced the production of anti-dsDNA antibody and IL-10
Rutz et al., Proc Natl Acad Sci U S A 2008 (Hypersensitivity, Delayed) : Dendritic cells ( DC ) selectively acquire Delta-like 4 expression upon stimulation with various Toll-like receptor ( TLR ) ligands and concomitantly induce IL-10 production by Th1 cells in vitro and in vivo
Jarnicki et al., J Immunol 2008 (MAP Kinase Signaling System...) : Inhibition of p38 suppressed TLR induced IL-10 and PGE ( 2 ) and enhanced IL-12 production in DC
Kalliolias et al., J Immunol 2008 : Strikingly, IL-27 strongly suppressed TLR induced IL-10 production in human monocytes
Qian et al., Inflamm Bowel Dis 2008 (Colitis) : HLA-B27 TG rats have an aberrant cell composition, altered functional TLR expression, and an intrinsic defect in IL-10 production in response to TLR ligands, which may result in exaggerated proinflammatory responses to commensal enteric bacteria and uncontrolled inflammation in this colitis model
Tachado et al., J Biol Chem 2008 (HIV Infections...) : As a functional assessment of GSK-3beta phosphorylation, TLR4 mediated interleukin-10 release was significantly higher in HIV+ human macrophages compared with healthy cells
Jose et al., Exp Lung Res 2009 : Prior studies by the authors revealed that Toll-like receptor ( TLR ) ligands inhibit IL-10 receptor signaling in alveolar macrophages ( AMOs ), thereby obviating the immunosuppressive activity of IL-10
Kaiser et al., J Exp Med 2009 : Here, we investigated the role of the TPL-2 signaling pathway in TLR induction of interferon-beta (IFN-beta) and interleukin-10 (IL-10) in these cell types
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Akitake et al., Gut 2010 (Autoimmune Diseases...) : Peripheral blood mononuclear cells ( PBMCs ) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor ( TLR ) ligands as compared with those from a healthy control
Amu et al., Scand J Immunol 2010 : We found that CD25 ( + ) B cells secreted higher levels of IL-6, IL-10 and INFgamma in response to different TLR-agonists , and were better at presenting alloantigen to CD4 ( + ) T cells
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Sindhava et al., PloS one 2010 : Here we discovered that peritoneal B-1 ( B-1P ) cells produce high levels of IL-10 upon stimulation with several Toll-like receptor ( TLR ) ligands ... IL-10 inhibits TLR induced B-1P cell activation by blocking the classical NF-kappaB pathway
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Chávez-Sánchez et al., Lipids in health and disease 2010 : The activation of CD14, TLR4 , and TLR2 by mmLDL induces IL-1ß, IL-6, and IL-10 secretion in human monocytes and macrophages
Okazaki et al., J Biochem 2011 : C5a controls TLR induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase ... Mouse macrophages produce IL-12 and IL-10 in response to TLR ligands such as LPS, CpG, Poly I:C and Malp2
den Hartog et al., PloS one 2011 : Recombinant bovine IL-10 inhibited TLR induced activation of monocytes, and dose-dependently inhibited LPS induced activation of monocyte derived DCs comparable to human IL-10
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Bzowska et al., Inflammation 2012 (Atherosclerosis...) : Oxidized LDLs inhibit TLR induced IL-10 production by monocytes : a new aspect of pathogen accelerated atherosclerosis
Ambarus et al., PloS one 2012 : In particular, HAGGs consistently enhanced the TLR induced IL-10 production in both classically and alternatively polarized macrophages ( M1 and M2 )
Movita et al., J Leukoc Biol 2012 : Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4, TLR7/8 , and TLR9 resulted in a weak induction of IL-10 , low or undetectable levels of IL-12p40 and TNF, and up-regulation of CD40 on the surface
Zamora et al., Cytokine 2012 : Even though TLR-activation induced TNFa, IL-10 and IL-6 production, only recombinant TNFa was able to downregulate CD36
Georg et al., Autoimmunity 2012 : They further show that pDC themselves produce IL-10 in response to TLR stimulation, most prominently after triggering of TLR7
Brisbin et al., Benef Microbes 2012 : The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10 , interferon-gamma and transforming growth factor beta
Miyazawa et al., J Biochem 2012 : However, Okazaki et al. ( C5a controls TLR induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase
Perugorria et al., Hepatology 2013 (Liver Cirrhosis...) : KCs lacking Tpl2 display defects with TLR induction of cytokines interleukin (IL)-1ß, IL-10 , and IL-23
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Gbédandé et al., Infect Immun 2013 (Malaria, Falciparum...) : Enhanced TLR mediated IL-10 responses at birth are associated with an increased risk of P. falciparum infection, suggesting a compromised ability to combat infection in early life
He et al., J Biol Chem 2013 : Additionally, IL-10 , TGF-ß1, peroxisome proliferator activated receptor ?, LIGHT ( TNF superfamily 14 ), and sphingosine kinase-1 were up-regulated, and such M2 polarization was dependent on TLR ligation