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ADCY4 — INS

Text-mined interactions from Literome

Shpakov et al., Biochemistry (Mosc) 2002 : We suggest that the stimulating effect of insulin on adenylate cyclase involves the following stages of hormonal signal transduction cascade : receptor tyrosine kinase -- > Gi protein ( betagamma ) -- > phosphatidylinositol 3-kinase -- > protein kinase C (zeta?) -- > Gs protein -- > adenylate cyclase -- > cAMP
Picinato et al., J Pineal Res 2002 : Melatonin also inhibited forskolin induced insulin secretion, a well known activator of adenylate cyclase ( AC ) activity
Salehi et al., Regul Pept 2007 : Four to six weeks later the pancreatic islets were isolated and analysed for cAMP or alternatively incubated in a Krebs-Ringer based medium in an effort to study insulin secretion and cAMP accumulation in response to glucose or the adenylate cyclase activator forskolin
Blazquez et al., Endocrinology 1976 : Development of insulin and glucagon binding and the adenylate cyclase response in liver membranes of the prenatal, postnatal, and adult rat : evidence of glucagon `` resistance ''
Kahn et al., J Biol Chem 1990 : Stimulation of prostaglandin E1 binding to human blood platelet membrane by insulin and the activation of adenylate cyclase
Larner et al., Adv Enzymol Relat Areas Mol Biol 1990 (Second Messenger Systems) : A cAMP dependent protein kinase inhibitory mediator, which also inhibits adenylate cyclase is an important element in the regulation of kinase and adenylate cyclase activity by insulin
Green et al., Horm Res 1979 : When islets were cultured in medium containing low glucose ( 5.5 mM ), the higher adenylate cyclase activity and insulin secretory responses characteristic of islets from pregnant rats were maintained during the test period of 29 h. Islets from normal and pregnant rats were also cultured for 20 h in medium containing a very high glucose concentration ( 83.3 mM ) in order to load the B cells with glycogen
Sadler et al., J Biol Chem 1987 : In contrast, insulin-like growth factor 1 stimulated in vivo phosphodiesterase, inhibited in vitro adenylate cyclase , and induced oocyte maturation at concentrations of 0.3-1.0 nM ... These results demonstrate a dual regulation of oocyte phosphodiesterase and adenylate cyclase by insulin and insulin-like growth factor 1
Bertrand et al., Biochem J 1989 : It is concluded that inhibition of adenylate cyclase , rather than direct changes in membrane K+ and Ca2+ permeabilities, underlies the inhibition of insulin release induced by activation of A1-receptors
Nesher et al., Diabetologia 1989 : ( 3 ) The early insulin response may be potentiated by direct activation of adenylate cyclase
Pyne et al., Biochem Biophys Res Commun 1989 : The ability of p [ NH ] ppG to inhibit forskolin stimulated adenylate cyclase activity was attenuated in the presence of insulin
Lönnqvist et al., International journal of obesity 1989 : Antilipolysis induced by insulin by adenylate cyclase inhibitors was compared in isolated human fat cells when lipolysis was activated at well defined steps in the cyclic AMP system
Bizec et al., Ophthalmic Res 1989 : Insulin was found to inhibit adenylate cyclase activity
Hermansen et al., Endocrinology 1985 : Forskolin, an activator of adenylate cyclase , stimulates pancreatic insulin , glucagon, and somatostatin release in the dog : studies in vitro
Mourmeaux et al., Endocrinology 1989 : In conclusion, acute stimulation of adenylate cyclase or protein kinase-C markedly increased insulin release from fetal islets without causing an adult-like biphasic pattern of secretion
Gabbay et al., FEBS Lett 1985 : The antilipolytic effect of insulin does not require adenylate cyclase or phosphodiesterase action
Kather et al., J Clin Invest 1985 : The findings support the view that the antilipolytic effect of insulin does not require adenylate cyclase or phosphodiesterase action
Heyworth et al., Biochem J 1986 : Treatment of hepatocytes with islet activating protein ( pertussis toxin ) from Bordetella pertussis blocked the ability of insulin to inhibit adenylate cyclase activity both in broken plasma membranes and in intact hepatocytes
Jones et al., FEBS Lett 1987 : These results suggest that catecholamines do not inhibit insulin secretion solely by reducing B-cell adenylate cyclase activity, and imply that one site of action of noradrenaline is at a late stage in the secretory process
Weber et al., J Cyclic Nucleotide Protein Phosphor Res 1986 : The intact rat adipocyte was used to investigate the possibility of common intermediates in the insulin stimulation of cyclic AMP phosphodiesterase and the beta-adrenergic/adenosine regulation of adenylate cyclase
Mooney et al., Endocrinology 1986 : Insulin had no effect on adenylate cyclase activity stimulated by either agent and assayed under essentially identical conditions ... Additionally, the antilipolytic effect of insulin was preserved in the permeabilized adipocytes, but this effect did not involve inhibition of adenylate cyclase
Gawler et al., Biochem J 1988 (Diabetes Mellitus, Experimental) : Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi ... Insulin caused the inhibition of glucagon stimulated adenylate cyclase activity in liver plasma membranes, but failed to inhibit this activity in liver membranes from rats made diabetic by treatment with either alloxan or streptozotocin ... We conclude that : ( i ) insulin does not inhibit adenylate cyclase activity through the inhibitory guanine nucleotide regulatory protein Gi ; ( ii ) streptozotocin- and alloxan induced diabetes elicit a selective insulin-resistant state; and (iii) metformin can exert a post-receptor effect, at the level of the liver plasma membrane, which restores the ability of insulin to inhibit adenylate cyclase
Abou-Sabe' et al., Biochim Biophys Acta 1978 : In vitro, the effect of insulin on the adenylate cyclase and the phosphotransferase activities was determined using toluenized cell preparations of E. coli B/r, E. coli K12 and phosphotransferase mutant strains
Londos et al., J Biol Chem 1985 : III. Multiple modes of insulin regulation of lipolysis and regulation of insulin responses by adenylate cyclase regulators
Bégin-Heick et al., Can J Physiol Pharmacol 1979 : In addition, the stimulatory effect of insulin on glucose incorporation into glycogen and its inhibitory action on adenylate cyclase activity were both blunted in the CA tissues
Kiss et al., Eur J Biochem 1979 : 1. The inhibitory effect of adenosine on the glucagon stimulated adenylate cyclase activity of liver plasma membranes, prepared from PVG/c rats, was potentiated by insulin
Gabbay et al., J Biol Chem 1984 : This demonstrates that insulin can antagonize cAMP stimulation of glycogenolysis independent of possible effects of insulin on adenylate cyclase or phosphodiesterase
Pohl et al., International journal of obesity 1981 : ( 3 ) Insulin stimulates cyclic AMP phosphodiesterase and inhibits adenylate cyclase in adipocytes
Honda et al., Nihon Naibunpi Gakkai Zasshi 1982 : The effect of insulin on adenylate cyclase of rat fat cells in the presence of theophylline ] ... Under these conditions, small but significant enhancement of adenylate cyclase activity, cAMP content and FFA accumulation by insulin alone was observed, while insulin remarkably inhibited adrenalin stimulated FFA accumulation, reducing adenylate cyclase activity and cAMP levels ... In summary, insulin , which is recognized as a typical antilipolytic hormone, activated adenylate cyclase and increased lipolysis at its physiological concentrations when it alone exerted its effect upon fat cells under the conditions where phosphodiesterase was completely inhibited by theophylline ... Accordingly, the present results indicate the bimodal effect of insulin on adenylate cyclase and lipolysis under the presence of theophylline ; enhancement when applied alone, and depression with adrenalin
Christoffersen et al., Eur J Biochem 1984 : Insulin added at the time of plating moderately increased the adenylate cyclase activity assayed at 48 h, while dexamethasone had no significant effect
Panagiotidis et al., Br J Pharmacol 1995 : SIN-1 did not influence insulin secretion induced by L-arginine or the adenylate cyclase activator, forskolin
Morris et al., Biochem J 1995 : It is suggested that insulin may reduce the level of phosphorylation of alpha-Gi-2 by stimulating intracellular protein phosphatase activity and that this action may offer a molecular explanation for the ability of insulin to inhibit adenylate cyclase activity in hepatocytes by increasing the level of non phosphorylated alpha-Gi-2
Rodriguez-Commes et al., Kidney Int 1994 : In contrast, insulin stimulated Ieq was independent of changes in cAMP, because insulin did not increase the accumulation of cAMP, and inhibition of adenylate cyclase with 2 ', 5 ' dideoxyadenosine did not affect transport