El-Metwally et al., J Clin Pathol 2006
(Carcinoma, Pancreatic Ductal...) :
When compared with untreated cells, cells treated with 100 nmol/l and 5 micromol/l atRA were observed to show ( 1 ) decreased proliferative activity ( cpm ) as indicated by decreased incorporation of thymidine labelled with hydrogen-3 ; ( 2 ) cell cycle arrest ; ( 3 ) increased apoptotic activity associated with p53 protein overexpression ; ( 4 ) upregulated expression of the transdifferentiation and redifferentiation markers ; ( 5 ) morphological changes indicative of transdifferentiation ( increased cell size and appearance of dendrites ) ; ( 6 ) decreased production of EGFR ; ( 7 ) upregulation of TGFalpha and TGFbeta2 ; and ( 8 ) increase in basal and glucose induced insulin secretion
Totsuka et al., Biochem Biophys Res Commun 1989
:
Stimulation of insulin secretion by transforming growth factor-beta ... Effects of transforming growth factor-beta ( TGF-beta ) on insulin secretion were studied in rat pancreatic islets
Sekine et al., Diabetes Res Clin Pract 1994
(Insulinoma...) :
Bimodal effect of transforming growth factor-beta on insulin secretion in MIN6 cells ... The effects of transforming growth factor-beta ( TGF-beta ) on insulin secretion were investigated using a glucose-responsive clonal cell line, MIN6