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NFKB1 — SLC22A3
Text-mined interactions from Literome
Huber et al., J Clin Invest 2004
(Breast Neoplasms...) :
Inhibition of
NF-kappaB signaling
prevented EMT in Ras transformed epithelial cells, while activation of this pathway promoted the transition to a mesenchymal phenotype even in the absence of TGF-beta
Huber et al., Cell cycle (Georgetown, Tex.) 2004
:
In a combined in vitro/in vivo model of mammary carcinogenesis,
NF-kappaB was
essential both for the induction and maintenance of
EMT and for in vivo metastasis
Sarkar et al., Int Rev Immunol 2008
(Cell Transformation, Neoplastic...) :
More importantly, recent studies have shown that
NF-kappaB signaling also
plays critical roles in the
epithelial-mesenchymal transition (EMT) and cancer stem cells
Zhang et al., Clin Cancer Res 2009
(Neoplasm Recurrence, Local...) :
In prostate cancer cell lines, TGF-beta induced
EMT was
mediated by
NF-kappaB signaling ... The detection of
NF-kappaB mediated TGF-beta induced
EMT in primary tumors predicts disease recurrence in prostate cancer patients following radical prostatectomy
Pantuck et al., Cancer Res 2010
(Carcinoma, Renal Cell...) :
Based on earlier evidence that VHL loss can activate NF-kappaB, a known mediator of EMT, we tested whether
NF-kappaB contributed to VHL mediated effects on
EMT