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CD8A — EOMES

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B) → EOMES (EOMES) (transcription, activates) Takemoto et al., J Immunol 2006
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Atreya et al., Gut 2007 (Colorectal Neoplasms...) : The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer ... CONCLUSION : These data define for the first time a regulatory role of eomesodermin for CD8 T cell activity in humans
Nayar et al., Proc Natl Acad Sci U S A 2012 : In contrast to WT cells, activation of IRF4-deficient CD8 ( + ) T cells leads to rapid and robust expression of Eomes , which is further enhanced by IL-4 stimulation