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Rao et al., Proc Natl Acad Sci U S A 2002
:
Finally, analysis of a ZAP-70-deficient T cell line revealed that Cbl inhibited Lck dependent mitogen activated protein kinase activation, and an intact Cbl RING finger domain was required for this functional effect
Maulon et al., Blood 1998
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Our results are consistent with a negative role for p56Lck on thrombin induced [ Ca2+ ] i release and p38 MAPK activation in Jurkat T-cell lines