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IL12B — MTOR
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kusaba et al., J Biol Chem 2005
:
IL-12 induced phosphorylation of Stat3 on Ser-727 was affected by rapamycin, which may be due to the effect of rapamycin on the
IL-12 induced interaction between
mammalian target of rapamycin (mTOR) and Stat3
Ohtani et al., Blood 2008
(Leishmaniasis, Cutaneous) :
Rapamycin, an inhibitor of mTOR, enhanced IL-12 production in LPS stimulated DCs, whereas the activation of
mTOR by lentivirus mediated transduction of a constitutively active form of Rheb
suppressed the production of
IL-12
Cheekatla et al., Med Microbiol Immunol 2012
(Leishmaniasis, Visceral) :
We show for the first time that in THP-1 derived macrophages and human monocytes,
mTOR inhibition by rapamycin reversed L. donovani
induced IL-12 and IL-10 modulation