◀ Back to MAPK15

IL4 — MAPK15

Text-mined interactions from Literome

Khan et al., J Immunol 1999 : We report that 1 ) the mature DN T cells are highly resistant to TCR cross-linking induced apoptosis in the presence of exogenous IL-4 ; 2 ) Fas/Fas-ligand and TNF-alpha/TNFR pathways do not play an apparent role in regulating apoptosis in DN T cells ; 3 ) the DN T cells constitutively express a high level of Bcl-xL, but not Bcl-2 ; 4 ) both Bcl-xL and Bcl-2 are up-regulated following TCR-cross linking ; and 5 ) IL-4 stimulation significantly up-regulates Bcl-xL and c-Jun expression and leads to mitogen activated protein kinase phosphorylation in DN T cells, which may contribute to the resistance to apoptosis in these T cells
Hirasawa et al., Biochim Biophys Acta 2000 : These findings suggest that the activation of PI3-kinase and p38 MAPK is partially responsible for the antigen induced IL-4 production in RBL-2H3 cells
Gingras et al., Mol Endocrinol 2000 (Breast Neoplasms) : In ZR-75-1 cells, both the activation of MAPK by IL-4 and the IL-4 induced 3beta-HSD activity were completely blocked by PD98059, an inhibitor of MAPK activation ... Wortmannin also blocked MAPK activation by IL-4 , IGF-I, and insulin, suggesting that the MAPK cascade acts as a downstream effector of PI 3-kinases
Wery-Zennaro et al., Oncogene 2000 (MAP Kinase Signaling System) : Here we provide evidence that p38 MAPK is activated in response to IL-4 and is involved in IL-6 synthesis by stabilizing IL-6 mRNA
Barna et al., Cell Immunol 2001 : Data suggest that astrocyte IL-4R alpha expression is upregulated by EGF but not by IL-4 in an EGF-receptor dependent manner and that mechanisms are independent of MAPK activation
Wei et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Consistent with this observation, the inhibitory effects of IL-4 on RANKL induced NF-kappa B and mitogen activated protein kinase activation are STAT6 dependent
McDermott et al., J Biol Chem 2002 : Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
Ihn et al., J Immunol 2002 (MAP Kinase Signaling System) : Furthermore, the p38 MAP kinase assay showed that IL-4 induces p38 MAPK activation in human dermal fibroblasts
Irusen et al., J Allergy Clin Immunol 2002 (Asthma) : Activation of p38 MAPK by IL-2 and IL-4 , as shown by means of phosphorylation of activated transcription factor 2, resulted in GR phosphorylation and reduced dexamethasone repression of LPS stimulated GM-CSF release
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Pesu et al., J Biol Chem 2002 : We found that the p38 MAPK inhibitor SB202190 as well as the dominant negative p38 MAPK inhibited interleukin (IL)-4 regulated expression of CD23 in Ramos B cells ... IL-4 stimulation did not stimulate p38 MAPK activity, but inhibition of p38 MAPK activity directly correlated with inhibition of IL-4 induced gene activation
Basaki et al., Arch Biochem Biophys 2002 (Burkitt Lymphoma) : We report here that CD40 induced TRAF3 dependent activation of mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase ( ERK ) kinase 1 ( MEK1 ) is involved in the upregulation of IL-4-driven germline C epsilon transcription in a human Burkitt 's lymphoma B cell line, DG75
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Jee et al., J Invest Dermatol 2002 (Carcinoma, Basal Cell...) : Next, interleukin-6 stimulation elicited extracellular signal regulated kinase activation in basal cell carcinoma cells, and the mitogen activated protein kinase inhibitor, PD98059, could affect this response without affecting the interleukin-6-medi ated Mcl-1 upregulation
Iwashita et al., Immunol Cell Biol 2003 (Colonic Neoplasms) : Interleukin-4 and IL-13 activated phosphorylation of mitogen activated protein kinase in LS174T cells
Mason et al., Infect Immun 2004 : TRAF6 dependent mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Prokopchuk et al., Br J Cancer 2005 (Pancreatic Neoplasms) : Interleukin-4 enhanced activity of MAPK , Akt-1, and Stat3 in IL-4-responsive, but not in IL-4-unresponsive MIA PaCa-2 cells ; however, IL-4 enhanced tyrosine phosphorylation of insulin receptor substrate-1 and -2 in all cell lines
Tamma et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : p38 MAPK plays a role in IL-4 synthesis in jacalin plus CD28 stimulated CD4+ T cells -- II
Ip et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System) : Inhibition of p38 MAPK , ERK and JAK-2 activities by pretreating the cells with their corresponding inhibitors SB203580, PD98059 and AG490, respectively, significantly suppressed IL-4- and IL-13 induced MCP-1 production in BEAS-2B cells
Liao et al., J Biomed Sci 2006 (MAP Kinase Signaling System...) : Although MAPK specific inhibitors suppressed LTC ( 4 ) and IL-4 , only U0126 inhibited the SP enhanced histamine release
Frossi et al., J Immunol 2007 : Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition
Hamdi et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : As a functional consequence of this PLD2 dependent MAPK activation, interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2
OuYang et al., Am J Pathol 2008 (Endometriosis) : IL-4 induced phosphorylation of p38 mitogen activated protein kinase, stress activated protein kinase/c-Jun kinase, and p42/44 mitogen activated protein kinase and inhibitors of these kinases suppressed IL-4 induced proliferation of endometriotic stromal cells
Ding et al., Journal of hematopathology 2009 : P38 mitogen activated protein kinase expression and regulation by interleukin-4 in human B cell non-Hodgkin lymphomas ... Interleukin-4 (IL-4) induced a dose dependent increase in the expression of p-p38 MAPK ( 1.6- to 2.8-fold ) in cell lines derived from activated B cell-like diffuse large B cell lymphoma ( DLBCL ) but not those from germinal center-like DLBCL ... The differential IL-4 regulation of p38 MAPK expression in cell lines derived from DLBCL may relate to the cellular origin of these neoplasms
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Glossop et al., J Tissue Eng Regen Med 2010 : In a previous gene expression study, we reported a potentially important role for mitogen activated protein kinase kinase kinase 8 ( MAP3K8 ) and interleukin-1ß ( IL-1B ) in MAPK signalling in MSCs exposed to fluid shear stress
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Cheng et al., J Cell Biochem 2011 : Previous studies have shown that IL-4 selectively blocks RANKL induced activation of NF-?B and mitogen activated protein kinase ( MAPK ) pathway molecules, suggesting that the cytokine arrests osteoclastogenesis by blockade of these signaling cascades
Dauphinee et al., Am J Physiol Heart Circ Physiol 2011 : We find that Ga ( i/o ) -mediated activation of the MAPK is independent of the canonical MyD88, interleukin-1 receptor associated kinase, and tumor necrosis factor receptor associated factor 6 signaling cascade in LPS stimulated cells
Zhou et al., J Immunol 2012 (Asthma...) : MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-ß1 and IL-13 in human airway fibroblasts
Tormos et al., Hepatology 2013 (Chronic Disease...) : p38a mitogen activated protein kinases ( MAPK ) may be essential in the up-regulation of proinflammatory cytokines and can be activated by transforming growth factor ß, tumor necrosis factor-a, interleukin-1ß , and oxidative stress
Marshall et al., J Immunol 1998 : IL-4 induced a late ( > 4-h ) increase in p38 MAPK activity and corresponding activation of its substrate MAPKAPK-2