Gene interactions and pathways from curated databases and text-mining

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GPR88 — MAPK8

Text-mined interactions from Literome

Smit et al., J Virol 2002 : Kaposi 's sarcoma associated herpesvirus encoded G protein coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G ( i ) and phospholipase C-dependent signaling pathways
Yart et al., J Biol Chem 2002 : Although Gbetagamma is thought to mediate mitogen activated protein kinase ( MAPK ) activation in response to G protein coupled receptor stimulation, the mechanisms involved in this pathway have not been clearly defined
Galaria et al., J Surg Res 2004 : This is the first description of differential MAPK regulation by a G-protein coupled receptor through the rho pathway
Scott et al., Mol Cell Biol 2006 : beta-Arrestins ( betaarr ) are multifunctional adaptor proteins that can act as scaffolds for G protein coupled receptor activation of mitogen activated protein kinases ( MAPK )
Sandhu et al., Eur J Pharmacol 2010 : We hypothesize that mitogen-activated-protein kinase ( MEK ) and/or extracellular-signal regulated kinase ( ERK ) specific inhibitors will attenuate the G-protein coupled receptor expression following organ culture
Schramek et al., Am J Physiol 1996 : To evaluate a possible mechanism for the chronic regulation of MEK and p42 MAPK, we studied the long-term effects of fetal bovine serum ( FBS ), the G protein coupled receptor agonist endothelin-1 (ET-1), and the protein tyrosine kinase coupled receptor agonist platelet derived growth factor BB ( PDGF BB ) on MEK and p42 MAPK in glomerular mesangial cells ( GMC )
Chatterjee et al., J Biol Chem 1997 : Here, we investigated the functional activity of RGS3 and a truncated form of RGS3 on G protein coupled receptor mediated activation of adenylyl cyclase, phosphoinositide phospholipase C, and mitogen activated protein kinase in intact cells
Guo et al., Eur J Biochem 1998 : Further studies indicate that Pyk2 phosphorylation, but not MAPK activation, is dependent on a pertussis toxin-sensitive G-protein coupled receptor as well as partially on actin cytoskeleton