◀ Back to CXCL12
CXCL12 — TERF2
Text-mined interactions from Literome
Katagiri et al., J Biol Chem 2004
:
In Jurkat T cells, TCR cross linking triggered persistent
Rap1 activation, and
SDF-1 ( CXCL12 )
activated Rap1 transiently
Kanemitsu et al., Blood 2005
:
In vitro,
CXCL13 activated the small guanosine triphosphatase ( GTPase )
Rap1 in B cells, and corroborating this observation, a deficiency of RAPL, the Rap1 effector molecule, caused a significant reduction in shear-resistant B-cell adhesion to intercellular adhesion molecule 1 ( ICAM-1 )
Glodek et al., Leukemia 2007
(Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) :
FAK-deficient REH cells also demonstrated reduced
CXCL12 induced activation of the GTPase
Rap1 , suggesting the importance of FAK in CXCL12 mediated integrin activation