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FYN — NTN1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) → netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) (modification, collaborate)
  Liu et al., J Neurosci 2007
  Evidence: physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) → p130 Cas (BCAR1) (modification, collaborate) Liu et al., J Neurosci 2007
  Evidence: physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) → p130 Cas (BCAR1) (modification, collaborate) Liu et al., J Neurosci 2007
  Evidence: physical interaction
• NCI Pathway Database Netrin-mediated signaling events: Fyn (FYN) → netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) (modification, collaborate)
  Liu et al., Nat Neurosci 2004, Ren et al., Nat Neurosci 2004, Li et al., Nat Neurosci 2004, Rajasekharan et al., Development 2009
  Evidence: physical interaction
• NCI Pathway Database Netrin-mediated signaling events: Fyn (FYN) → netrin 1/DCC/FAK complex (NTN1-DCC-PTK2) (modification, collaborate)
  Liu et al., Nat Neurosci 2004, Ren et al., Nat Neurosci 2004, Li et al., Nat Neurosci 2004, Rajasekharan et al., Development 2009
  Evidence: physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) → netrin 1/DCC/FAK complex (NTN1-DCC-PTK2) (modification, collaborate)
  Liu et al., Nat Neurosci 2004, Ren et al., Nat Neurosci 2004, Li et al., Nat Neurosci 2004, Rajasekharan et al., Development 2009
  Evidence: physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) → RHOA/GTP complex (RHOA) (modification, activates) Moore et al., Development 2008, Rajasekharan et al., Development 2009, Rajasekharan et al., J Neurochem 2010
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) → None (modification, activates) Moore et al., Development 2008, Rajasekharan et al., Development 2009, Rajasekharan et al., J Neurochem 2010
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: None → netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) (modification, collaborate)
  Liu et al., J Neurosci 2007
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: RAC1/GDP complex (RAC1) → netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) (modification, collaborate)
  Liu et al., J Neurosci 2007
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) → RAC1/GTP complex (RAC1) (modification, activates) Liu et al., J Neurosci 2007
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn/p130 CAS complex (NTN1-DCC-PTK2-FYN-BCAR1) → None (modification, activates) Liu et al., J Neurosci 2007
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: Fyn (FYN) → netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) (modification, activates)
  Liu et al., Nat Neurosci 2004, Ren et al., Nat Neurosci 2004, Li et al., Nat Neurosci 2004
  Evidence: assay
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/UNC5C complex (NTN1-DCC-UNC5C) → netrin 1/DCC/UNC5C/FAK/Src-Yes-Fyn complex (NTN1-DCC-UNC5C-PTK2-YES1_SRC_FYN) (modification, collaborate)
  Li et al., J Cell Sci 2006
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/UNC5C complex (NTN1-DCC-UNC5C) → Src-Yes-Fyn (YES1/SRC/FYN) (modification, collaborate)
  Li et al., J Cell Sci 2006
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/UNC5C/FAK/Src-Yes-Fyn complex (NTN1-DCC-UNC5C-PTK2-YES1_SRC_FYN) → Src-Yes-Fyn (YES1/SRC/FYN) (modification, collaborate)
  Li et al., J Cell Sci 2006
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/UNC5C/FAK/Src-Yes-Fyn complex (NTN1-DCC-UNC5C-PTK2-YES1_SRC_FYN) → FAK (PTK2) (modification, collaborate) Li et al., J Cell Sci 2006
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: FYN → NTN1 (reaction) Shekarabi et al., Mol Cell Neurosci 2002, Liu et al., Nat Neurosci 2004, Li et al., Nat Neurosci 2004, Meriane et al., J Cell Biol 2004, Shekarabi et al., J Neurosci 2005, Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008, Ren et al., Neurosignals 2008
• Reactome Reaction: FYN → NTN1 (indirect_complex) Liu et al., Nat Neurosci 2004, Li et al., Nat Neurosci 2004, Meriane et al., J Cell Biol 2004, Ren et al., Neurosignals 2008

Text-mined interactions from Literome

Ren et al., Neurosignals 2008 : In addition, we show that tyrosine phosphorylated DCC selectively interacts with the Src family kinases Fyn and Lck, but not Src, c-Abl, Grb2, SHIP1, Shc, or tensin, suggesting a role of Fyn or Lck in netrin-1-DCC signaling
Purohit et al., J Biol Chem 2012 : Netrin-1 increases tyrosine phosphorylation of endogenous DSCAM, UNC5C, FAK, Fyn , and PAK1, and promotes complex formation of DSCAM with these signaling molecules in primary postnatal cerebellar neurons ... The knockdown of DSCAM inhibits netrin induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn ... The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1