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FYN — PIK3CA

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: FYN/LCK → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Cholinergic synapse: FYN → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991
  Evidence: assay, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991
  Evidence: assay, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991
  Evidence: assay, other species
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Antigen/IgE/Fc epsilon R1/Fyn complex (FYN-FCER1A-MS4A2-IGHE-FCER1G) → GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Antigen/IgE/Fc epsilon R1/Fyn complex (FYN-FCER1A-MS4A2-IGHE-FCER1G) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  
• Reactome Reaction: FYN → PIK3CA (reaction) Jiang et al., J Immunol 2002, Kane et al., Immunol Rev 2003*, Moon et al., J Biol Chem 2005, Sun et al., J Biol Chem 2008, Odai et al., J Biol Chem 1995, Pagès et al., J Biol Chem 1996*, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998
• Reactome Reaction: FYN → PIK3CA (indirect_complex) Jiang et al., J Immunol 2002, Kane et al., Immunol Rev 2003*, Moon et al., J Biol Chem 2005, Dufour et al., Bone 2008, Sun et al., J Biol Chem 2008, Odai et al., J Biol Chem 1995, Pagès et al., J Biol Chem 1996*, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998
• WikiPathways Focal Adhesion: FYN → PIK3CA/PIK3CD/PIK3R1/PIK3R2/PIK3CG/PIK3R5/PIK3R4/PIK3CB (activation)
  

Text-mined interactions from Literome

Bernardini et al., FASEB J 2005 : Our observations indicate that chemoattractant receptor engagement induces Fyn dependent PI 3K activation in association with LFA-1 and suggests that Fyn is necessary to initiate and/or to regulate chemoattractant mediated LFA-1 activation to promote directional migration
Salmond et al., J Immunol 2009 : We show that maximal TCR induced rpS6 phosphorylation in CD8 T cells requires both Lck and Fyn activity and downstream activation of PI3K , mTOR, and MEK/ERK MAPK pathways
Yadav et al., Mol Carcinog 2011 : Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration ... In addition, expression of Fyn in MDA-MB-231 breast cancer cells was dependent on PI3K activity and was involved in their invasive phenotype
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Whereas Src kinases are often required for Syk activation, we show here that PI3K/Akt activation and autocrine IL-10 production by NGFR-LMP1 involves the Src family kinase Fyn