◀ Back to LEP

CASP4 — LEP

Text-mined interactions from Literome

Kim et al., J Biol Chem 2003 : Further investigation demonstrated that leptin activated caspase-3 and caspase-9, but not caspase-8, and increased the cleavage of poly- ( ADP-ribose ) polymerase and cytochrome c release into cytosol ... PD98059, U0126, and AACOCF3 also diminished the leptin induced cytochrome c release into cytosol, cell death, and caspase-3 activation
Slomiany et al., Biochem Biophys Res Commun 2003 (Bacteroidaceae Infections) : The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin, an inhibitor of PI3K, which also obviated the inhibitory effect of leptin on the LPS induced upregulation in apoptosis, caspase-3 activity, and NO generation
Gregoraszczuk et al., J Reprod Dev 2005 : During the early luteal phase, leptin at all used doses had no effect on basal P4 secretion, but it did suppress caspase-3 activity ... In mature corpora lutea of full secreting capacity, leptin at all doses had no effect on basal and GH-stimulated P4 secretion and caspase-3 activity
Gregoraszczuk et al., Acta Vet Hung 2006 : Leptin increased E2 secretion and significantly diminished caspase-3 activity at all doses used
Ahmed et al., J Vet Med Sci 2007 : However, leptin treatment increased monocyte/macrophages production of IL-1beta as well as TNF-alpha, and induced the mRNA expression of caspase-1 , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms
Ercan et al., J Gastroenterol 2007 : In this study, we investigated the effect of leptin on caspase-3, caspase-8 , and caspase-9 immunoreactivity and lipid peroxidation in the stomachs of rats exposed to cold-restraint stress
Maedler et al., FASEB J 2008 (Diabetes Mellitus, Type 2) : Similarly, cultured human islets exposed to high glucose- and leptin induced caspase 1 and JNK inhibition prevented this up-regulation
Zhang et al., Eur J Pharmacol 2011 (Brain Ischemia...) : Furthermore, leptin also promoted bcl-2 expression and suppressed caspase-3 in vivo and vitro after injury
Fernández-Martos et al., PloS one 2012 (Inflammation...) : Moreover, leptin administered after spinal cord injury increased the expression of neuroprotective genes, reduced caspase-3 activity and decreased the expression of pro-inflammatory molecules
Liu et al., Zhonghua Jie He He Hu Xi Za Zhi 2012 : Leptin inhibited the activation of caspase-3 in the negative way
Ptak et al., Toxicol In Vitro 2013 (MAP Kinase Signaling System...) : This study was designed to investigate the effect of bisphenol A and leptin on caspase-3 expression and activity in OVCAR-3 ovarian cancer cells ... 17ß-estradiol ( 40nM ) was used as a positive control for estrogenic properties of bisphenol A. Results showed that the interaction between bisphenol A and leptin , which was similar to that observed between 17ß-estradiol and leptin, led to the inhibition of caspase-3 expression and activity in OVCAR-3 cells ... Also, results showed that leptin inhibits caspase-3 activity by acting on the signal transducers and activators of transcription 3 ( STAT3 ) pathway, but bisphenol A and 17ß-estradiol by the extracellular-signal regulated kinases 1/2 ( ERK1/2 ) pathway ... In conclusion, the study reveals that bisphenol A and leptin interact to inhibit caspase-3 expression and activity by modulating STAT3 and ERK1/2 signaling pathways in OVCAR-3 cells