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CASP9 — TCF12
Text-mined interactions from Literome
Glasgow et al., Neurochem Res 2000
(Neurodegenerative Diseases) :
Key in these cascades is the
activation of the
caspase and Bcl-family of proteins by the NF-kappaB
transcription factor
Chen et al., Cancer Res 2003
(Colonic Neoplasms) :
Consistent with Wnt pathway involvement, dominant negative
TCF/LEF induced
caspase protein expression
Jiménez Del Río et al., Arch Med Res 2004
(Necrosis...) :
All metals induced mitochondrial depolarization ( 17-62 % nonfluorescent cells ) and
activated caspase-3 concomitantly with apoptotic morphology ( 25-32 % AO/EB ) at 24 h, and neither NF-kappaB nor p53
transcription factor showed activation
Cao et al., J Immunol 2004
:
The E2F-1
transcription factor promotes
caspase-8 and bid expression, and enhances Fas signaling in T cells
Jover-Mengual et al., Endocrinology 2007
(Ischemia...) :
We demonstrate that global ischemia promotes early dephosphorylation and inactivation of ERK1 and the
transcription factor cAMP-response element binding protein ( CREB ), subsequent down-regulation of the antiapoptotic protein Bcl-2, a known gene target of estradiol and CREB, and
activation of
caspase-3
Siu et al., Proteomics 2008
(Carcinoma, Non-Small-Cell Lung...) :
In particular, elevated expression of C/EBP homologous
transcription factor ( chop ) and
activation of
caspase-4 occurred at early time point ( 8 h ) of PD treatment, signifying an initial ER stress mediated apoptosis
Jover-Mengual et al., Brain Res 2010
(Brain Ischemia...) :
We demonstrate that global ischemia promotes early
activation of glycogen synthase kinase-3beta ( GSK3beta ) and forkhead
transcription factor of the O class ( FOXO)3A, known Akt targets that are related to cell survival, and activation of
caspase-3
Frisan et al., Blood 2012
(Myelodysplastic Syndromes) :
Normal human erythroid cell maturation requests the
transcription factor GATA-1 and a transient
activation of
caspase-3 , with GATA-1 being protected from caspase-3 mediated cleavage by interaction with the chaperone heat shock protein 70 ( Hsp70 ) in the nucleus