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ADAM17 — EGFR

Text-mined interactions from Literome

Borrell-Pagès et al., EMBO J 2003 (Breast Neoplasms...) : TACE is required for the activation of the EGFR by TGF-alpha in tumors
Shao et al., Proc Natl Acad Sci U S A 2003 : We hypothesized that TACE increases the shedding of TGF-alpha, resulting in EGFR phosphorylation and inducing mucin production in human airway epithelial ( NCI-H292 ) cells
Tanida et al., Gastroenterology 2004 (Stomach Neoplasms) : Although this EGFR transactivation reportedly requires a disintegrin and metalloproteinase ( ADAM ) that sheds the ectodomain of EGFR ligands, the detailed mechanisms are still unknown
Deshmukh et al., Am J Respir Crit Care Med 2005 : Together, these data suggest that acrolein induces MUC5AC expression via an initial ligand dependent activation of EGFR mediated by ADAM17 and MMP9
Itoh et al., Cytokine 2005 (Carcinoma...) : IL-8 transiently induced EGFR tyrosine phosphorylation after 5-90 min and this was completely inhibited by ADAM inhibitor
Joh et al., Dig Dis Sci 2005 : Helicobacter pylori stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase ( ADAM ) activation
Ohtsu et al., Am J Physiol Cell Physiol 2006 : The major focus of the review will be on the possible upstream mechanisms of ADAM activation by GPCRs as well as downstream signal transduction and the pathophysiological significances of ADAM dependent EGFR transactivation
Bech-Serra et al., Mol Cell Biol 2006 (Neoplasms) : Activation of the epidermal growth factor receptor leads to the upregulation of the shedding of Dsg-2 and to the concomitant upregulation of ADAM17 , but not ADAM10, supporting the ability of overexpressed ADAM17 to shed Dsg-2
Ohtsu et al., Arterioscler Thromb Vasc Biol 2006 (Hypertrophy) : ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II ... ADAM17 activated by the AT1 receptor is responsible for EGFR transactivation and subsequent protein synthesis in VSMCs
Küper et al., Am J Physiol Cell Physiol 2007 : Conversely, TACE inhibition prevented TGF-alpha release ; EGFR , p38, and ERK1/2 activation ; and COX-2 expression
Sternlicht et al., J Mammary Gland Biol Neoplasia 2008 (Breast Neoplasms) : Thus proper mammary morphogenesis requires the ADAM17 mediated release of AREG from ductal epithelial cells, the subsequent activation of EGFR on stromal cells, and EGFR dependent stromal responses that in return elicit a new set of epithelial responses, all culminating in the formation of a fully functional ductal tree
Yin et al., Invest Ophthalmol Vis Sci 2009 : Taken together, our data suggest that in addition to functioning as an EGFR downstream effector, ERK1/2 also mediates ADAM dependent HB-EGF shedding and subsequent EGFR transactivation in response to a variety of stimuli, including wounding and GPCR ligands
Boots et al., J Biol Chem 2009 : Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation
Bakken et al., J Vasc Surg 2009 : To determine the role of ADAM in EGFR transactivation by ATF in human vascular smooth muscle cells ( VSMC ) during cell migration
Melenhorst et al., American journal of physiology. Renal physiology 2009 (Fibrosis...) : In mice, angiotensin II infusion induces renal fibrosis via ADAM17 mediated TGF-alpha shedding and subsequent EGFR activation
Kasina et al., Cell Prolif 2009 : ADAM mediated amphiregulin shedding and EGFR transactivation ... These data also show that CXCL12 mediated cellular proliferation requires EGFR transactivation in a Src- and ADAM dependent manner in non transformed prostate epithelial cells
Baumgart et al., Cancer Res 2010 (Carcinoma, Non-Small-Cell Lung...) : ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer ... ADAM17 induces activation of the EGFR through ligand cleavage
Dey et al., J Pharmacol Exp Ther 2010 : Bradykinin decreases podocyte permeability through ADAM17 dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement
Kakiashvili et al., J Biol Chem 2011 (MAP Kinase Signaling System) : In summary, in the present study we show that the TNF-a induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE dependent EGFR activation
Takaguri et al., Hypertension 2011 (Carotid Artery Injuries...) : In conclusion, ADAM17 activation is involved in epidermal growth factor receptor activation and subsequent neointimal hyperplasia after vascular injury
Sanchez-Guerrero et al., PloS one 2012 : This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and MMP/ADAM dependent EGFR phosphorylation
Hall et al., Mol Cell Biol 2013 (Hypertrophy) : ADAM17 releases growth factors, cytokines, and other membrane proteins from cells and is essential for epidermal growth factor receptor (EGFR) signaling and for processing tumor necrosis factor alpha