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EGFR — JAK1

Pathways - manually collected, often from reviews:

• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → JAK1 (modification, activates)
• KEGG Pathways in cancer: EGFR → JAK1 (protein-protein, activation)
• KEGG Pancreatic cancer: Complex of EGFR-ERBB2 → JAK1 (protein-protein, activation)
• WikiPathways TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer: EGFR → JAK1 (activation)
• WikiPathways TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer: EGFR → JAK1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: JAK1 — EGFR (physical association, affinity chromatography technology) Tong et al., J Proteome Res 2008
• IRef Innatedb Interaction: JAK1 — EGFR (unknown, -) Andl et al., Am J Physiol Gastrointest Liver Physiol 2004

Text-mined interactions from Literome

Lee et al., Mol Cancer Ther 2006 (Carcinoma, Squamous Cell...) : We conclude that SOCS-1 methylation status can differentially affect STAT3 activation by IL-6R and EGFR through JAK or MEK in different HNSCC and response to pharmacologic antagonists
Bauer et al., Cell Host Microbe 2012 : We find that hBD3 is highly active against H. pylori in vitro and is rapidly induced during early infection via EGFR dependent activation of MAP kinase and JAK/STAT signaling