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CCND1 — IGF1

Text-mined interactions from Literome

Dupont et al., Mol Pathol 2001 (Breast Neoplasms) : Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein ( RB )
Takahashi et al., Biochim Biophys Acta 2001 : In addition, these inhibitors depressed the synergistic increase in cyclin D1 and cyclin D- or cyclin E-associated cyclin dependent kinase (CDK) activity that is induced by TSH and IGF-I
You et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1 induced upregulation of Pin1, cyclin D1 and RB phosphorylation
Cui et al., Mol Endocrinol 2003 (Breast Neoplasms) : Second, whereas PR and cyclin D1 are both ER up-regulated, IGF-I increased cyclin D1 levels while decreasing PR levels
Dupont et al., J Biol Chem 2003 (Breast Neoplasms) : This latter result is explained by a delay in G1 to S cell cycle progression due partly to a reduction in the activation of some components of cell cycle including the induction of cyclin D1 expression in response to IGF-1
Surmacz et al., Cancer Res 1992 (Leukemia, Promyelocytic, Acute) : Insulin-like growth factor 1 by itself does not induce cyclin D1 expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth regulated levels of cyclin D1 mRNA
Frederick et al., Mol Cell Neurosci 2004 : IGF-I and FGF-2 coordinately enhance cyclin D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells ... IGF-I enhanced FGF-2 induction of cyclin D1 , activation of G ( 1 ) cyclin-cyclin dependent kinase (cdk) complexes, and hyperphosphorylation of retinoblastoma protein ( pRb )
Zhang et al., J Biol Chem 2004 : This effect was also associated with a reduction in IGF-I induced cyclin D1 expression
von Wichert et al., Oncogene 2005 (Neuroendocrine Tumors) : Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells ... Here we examine the regulation of cyclin D1 expression by endogenously released IGF-I in BON cells ... Ras- and Rac-GTPases were found to be upstream activators of cyclin D1 expression, whereas protein kinase B/AKT and nuclear factor kappa B (NFkappaB) could be established as downstream mediators of cyclin D1 transcription in response to endogenously released IGF-I in these cells
Mawson et al., Mol Cell Endocrinol 2005 (Breast Neoplasms) : Therefore, estrogen and insulin/IGF-1 differentially regulate c-Myc and cyclin D1 to cooperatively stimulate breast cancer cell proliferation
Zhang et al., J Mol Endocrinol 2005 (Breast Neoplasms...) : Moreover, these same IGF-I induced responses were also inhibited by the antiestrogen ICI 182780 and this was in contrast to a previous report suggesting that ICI 182780 did not affect IGF-I dependent activation of PI3-K or induction of cyclin D1 expression
Haluska et al., Cancer Res 2006 (Breast Neoplasms...) : At doses that inhibited proliferation, the compound also caused a G0-G1 arrest and prevented nuclear accumulation of cyclin D1 in response to LR3 IGF-I
Jiang et al., J Cell Biochem 2006 (Hypertrophy) : IGF-1 increases laminin, cyclin D1 , and p21Cip1 expression in glomerular mesangial cells : an investigation of the intracellular signaling pathway and cell-cycle progression ... Here, we investigate IGF-1 regulation of laminin, an extracellular matrix ( ECM ) component, and cyclin D1 and p21Cip1, cell-cycle progression factor, expressions in glomerular mesangial cells ... Surprisingly, IGF-1 activates the expression of both cyclin D1 and cell-cycle arrest factor, p21Cip1 parallely ... Pharmacological inhibition of calcineurin by cyclosporin A blocks IGF-1 induced cyclin D1 and p21Cip1expression significantly ( P < 0.05 )
Bridle et al., J Lab Clin Med 2006 : PDGF and IGF-1 also increased the levels of cyclin D1 and phospho-glycogen synthase kinase-3beta
Kalluri et al., Eur J Neurosci 2007 : Accordingly, stimulation of the ERK pathway by FGF-2 induced the expression of cyclin D1, which is essential for the entry of cells into cell cycle, and IGF-I in the presence of FGF-2 up-regulated the expression of cyclin D1
Frederick et al., Glia 2007 (MAP Kinase Signaling System) : Synergistic induction of cyclin D1 in oligodendrocyte progenitor cells by IGF-I and FGF-2 requires differential stimulation of multiple signaling pathways ... Moreover, the presence of IGF-I significantly enhances nuclear localization of cyclin D1 , which also requires PI3K signaling ... Thus, we provide a model for cyclin D1 coordinate regulation where FGF-2 stimulation of the MAPK pathway promotes cyclin D1 mRNA expression while IGF-I activation of the PI3K pathway inhibits proteasome degradation of cyclin D1 and enhances nuclear localization of cyclin D1
Fukushima et al., Endocrinology 2008 : We found that cAMP pretreatment enhanced IGF-I dependent increases in cyclin D1 , due to synergistic increases in mRNA and elevation of translation rates ... In contrast, IGF-I dependent PI 3-kinase activation was required for the increase in cyclin D1 mRNA levels and degradation of p27 ( Kip1 )
Jones et al., Mol Cancer Res 2008 (Mammary Neoplasms, Animal) : Characterization of a novel primary mammary tumor cell line reveals that cyclin D1 is regulated by the type I insulin-like growth factor receptor
Ren et al., Acta Pharmacol Sin 2009 : In the present study, we investigated the effect of IGF-1 on the expression of cyclin D1, an important cell cycle regulatory protein, and a signaling pathway involved in IGF-1 's effect on cyclinD1 expression in FRTL thyroid cells ... IGF-1 increased the cyclin D1 expression in thyroid cells
Mairet-Coello et al., J Neurosci 2009 : IGF-1 induced rapid increases in cyclin D1 and D3 protein levels at 4 h and cyclin E at 8 h
Broussas et al., Int J Cancer 2009 (MAP Kinase Signaling System) : Cell cycle progression and colony formation were affected in the presence of h7C10 probably because of the inhibition of IGF-1 induced cyclin D1 and E expression
Sun et al., Oncogene 2009 : We found previously that in intestinal cells, insulin or insulin-like growth factor-1 stimulates c-Myc and cyclin D1 protein expression through both Akt dependent and Akt independent mechanisms
Pongsavee et al., International journal of molecular sciences 2009 : It is presumed that estrogen and insulin/IGF-1 regulate c-Myc and cyclin D1 during breast cancer cell proliferation
Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt, mTOR, p70S6K, 4EBP and cyclin D1
Borowiec et al., Biochim Biophys Acta 2011 (Ion Channel Gating) : Regulation of IGF-1 dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells : the critical role of hEag1 channels in G1 phase progression ... As expected, IGF-1 increased cyclin D1 and E expression of MCF-7 cells in a cyclic manner, whereas the increase of CDK4 and 2 levels was sustained ... This study is the first to demonstrate that K ( + ) channels such as hEag1 are directly involved in the IGF-1 induced up-regulation of cyclin D1 and E expression in MCF-7 cells
Devi et al., Biochim Biophys Acta 2011 (Diabetic Retinopathy) : However, stable transfection of a mutant GSK3ß ( S9A ) or a dominant negative K-CREB in TR-iBRB2 prevents IGF-1 induced fibronectin and cyclin D1 expression
Yan et al., Dev Neurobiol 2013 : To elucidate the mechanism of IGF-I actions on neural cell proliferation, we utilized a rat oligodendroglial cell line ( OL-1 ) and primary oligodendrocyte precursors ( OPC ) and studied IGF-I regulation of cyclin D1 expression and its promoter activity, because cyclin D1 is critical to the promotion of cell proliferation and cell cycle progression ... Transient transfection of a reporter driven by the rat cyclin D1 promoter showed that IGF-I stimulates cyclin D1 promoter activity ... Furthermore, 5'-end deletions and mutation analysis of this promoter revealed that a cAMP response element ( CRE ) within -174 base pair ( bp ) upstream of the transcription start site is crucial to the IGF induced increase in cyclin D1 transcription ... Consistently, Western immunoblot analysis demonstrated that IGF-I induced CREB ( CRE binding protein ) phosphorylation, while ablation of CREB expression with small interfering RNAs ( siRNA ) blocked IGF-I actions on cyclin D1 mRNA expression and cell proliferation ... Taken together, our data indicate that IGF-I upregulates cyclin D1 transcription partially by inducing CREB phosphorylation through the ERK-MAP kinase pathway, and thus increasing its recruitment to the cyclin D1 promoter
Kalita et al., IUBMB Life 2013 : In this study, a robust cyclin D1 expression was observed following IGF-1 stimulation in SY5Y cells as well as neurospheres ... Together, these findings shed new light on the mechanism of IGF-1 mediated upregulation of cyclin D1 expression in neural cell lines as well as in neural stem cells via the JAK/STAT5 signaling cascade
Furlanetto et al., Mol Endocrinol 1994 (Bone Neoplasms...) : Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro
Dufourny et al., J Biol Chem 1997 (Breast Neoplasms) : In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells