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OPN1MW — TRPV1

Text-mined interactions from Literome

Bisogno et al., Br J Pharmacol 2001 : 3. Both CBD and ( + ) -CBD, but not the other analogues, stimulated VR1 with EC ( 50 ) =3.2 - 3.5 microM, and with a maximal effect similar in efficacy to that of capsaicin, i.e. 67 - 70 % of the effect obtained with ionomycin ( 4 microM )
Arnold et al., Pharmacol Rep 2012 : The effects of CBD were not mediated by either CB(2) or TRPV(1) receptors alone, however, required activation of both these receptors to modulate MDR1 mRNA expression