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SMAD6 — TGFB3
Text-mined interactions from Literome
Chipuk et al., J Biol Chem 2002
(Adenocarcinoma...) :
In the prostate, androgens negatively regulate the expression of
transforming growth factor-beta ( TGF-beta ) ligands and receptors and
Smad activation through unknown mechanisms
Prokova et al., J Biol Chem 2002
(Cell Transformation, Neoplastic) :
Inhibition of
transforming growth factor beta signaling and
Smad dependent
activation of transcription by the Latent Membrane Protein 1 of Epstein-Barr virus
Chai et al., J Biol Chem 2003
:
The
Smad family of proteins
mediates transforming growth factor-beta signaling from cell membrane to the nucleus
Mori et al., Int J Cancer 2003
(Carcinoma, Hepatocellular...) :
Repression of
Smad dependent
transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB
Wang et al., J Biol Chem 2005
:
Recently, we found that enforced expression of ARA55 inhibits
transforming growth factor-beta mediated up-regulation of
Smad binding element-luciferase reporter activity in NRP-154 and NRP-152 rat prostate and LNCaP human prostate cell lines
Inamoto et al., Oncogene 2007
:
Crk associated substrate lymphocyte type
regulates transforming growth factor-beta signaling by inhibiting
Smad6 and Smad7
Li et al., Circ Res 2008
:
Atrial natriuretic peptide inhibits
transforming growth factor beta induced
Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
Horie et al., J Lipid Res 2008
:
One of the genes identified was TG-interacting factor (TGIF), a DNA binding homeodomain protein that has been demonstrated to suppress
Smad mediated activation of
transforming growth factor beta ( TGF-beta ) -regulated transcription
Truty et al., J Biol Chem 2009
:
The
role of
non-Smad proteins in the regulation of
transforming growth factor-beta ( TGFbeta ) signaling is an emerging line of active investigation
Kim et al., J Cell Biochem 2009
:
Transforming growth factor-beta3 induced
Smad signaling regulates actin reorganization during chondrogenesis of chick leg bud mesenchymal cells ... In conclusion, our results indicate that
TGF-beta3 induced
Smad signaling, in conjunction with beta-catenin, is involved in the reorganization of the actin cytoskeleton into a cortical pattern with a concomitant rounding of cells
Lee et al., Mol Biol Cell 2009
(Teratocarcinoma) :
Here, we report that although the
transforming growth factor ( TGF ) -beta type III receptor ( TbetaRIII ) enhanced both ALK3 and ALK6 signaling, TbetaRIII more potently
enhanced ALK6 mediated stimulation of the BMP-responsive promoters XVent2 and 3GC2, and up-regulation of the early response gene
Smad6
Eloy et al., Virchows Arch 2012
(Carcinoma...) :
It was also shown that
transforming growth factor beta ( TGF-beta )
/Smad dependent pathway activity is associated with local invasion, nodal metastatization and BRAF mutated PTCs