Gene interactions and pathways from curated databases and text-mining

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SMAD6 — TGFB3

Text-mined interactions from Literome

Chipuk et al., J Biol Chem 2002 (Adenocarcinoma...) : In the prostate, androgens negatively regulate the expression of transforming growth factor-beta ( TGF-beta ) ligands and receptors and Smad activation through unknown mechanisms
Prokova et al., J Biol Chem 2002 (Cell Transformation, Neoplastic) : Inhibition of transforming growth factor beta signaling and Smad dependent activation of transcription by the Latent Membrane Protein 1 of Epstein-Barr virus
Chai et al., J Biol Chem 2003 : The Smad family of proteins mediates transforming growth factor-beta signaling from cell membrane to the nucleus
Mori et al., Int J Cancer 2003 (Carcinoma, Hepatocellular...) : Repression of Smad dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB
Wang et al., J Biol Chem 2005 : Recently, we found that enforced expression of ARA55 inhibits transforming growth factor-beta mediated up-regulation of Smad binding element-luciferase reporter activity in NRP-154 and NRP-152 rat prostate and LNCaP human prostate cell lines
Inamoto et al., Oncogene 2007 : Crk associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7
Li et al., Circ Res 2008 : Atrial natriuretic peptide inhibits transforming growth factor beta induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
Horie et al., J Lipid Res 2008 : One of the genes identified was TG-interacting factor (TGIF), a DNA binding homeodomain protein that has been demonstrated to suppress Smad mediated activation of transforming growth factor beta ( TGF-beta ) -regulated transcription
Truty et al., J Biol Chem 2009 : The role of non-Smad proteins in the regulation of transforming growth factor-beta ( TGFbeta ) signaling is an emerging line of active investigation
Kim et al., J Cell Biochem 2009 : Transforming growth factor-beta3 induced Smad signaling regulates actin reorganization during chondrogenesis of chick leg bud mesenchymal cells ... In conclusion, our results indicate that TGF-beta3 induced Smad signaling, in conjunction with beta-catenin, is involved in the reorganization of the actin cytoskeleton into a cortical pattern with a concomitant rounding of cells
Lee et al., Mol Biol Cell 2009 (Teratocarcinoma) : Here, we report that although the transforming growth factor ( TGF ) -beta type III receptor ( TbetaRIII ) enhanced both ALK3 and ALK6 signaling, TbetaRIII more potently enhanced ALK6 mediated stimulation of the BMP-responsive promoters XVent2 and 3GC2, and up-regulation of the early response gene Smad6
Eloy et al., Virchows Arch 2012 (Carcinoma...) : It was also shown that transforming growth factor beta ( TGF-beta ) /Smad dependent pathway activity is associated with local invasion, nodal metastatization and BRAF mutated PTCs