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SRC — WNK4

Text-mined interactions from Literome

Yue et al., Proc Natl Acad Sci U S A 2009 : Moreover, expression c-Src diminished the SGK1 mediated increase in serine phosphorylation of WNK4 , suggesting that c-Src enhances WNK4 mediated inhibition of ROMK channels by suppressing the SGK1 induced phosphorylation
Lin et al., American journal of physiology. Renal physiology 2012 : Moreover, expression of c-Src inhibited SGK1 induced phosphorylation of WNK4 but not WNK4 ( -PP1#1 ) at serine residue 1196 ( Ser ( 1196 ) ) ... In contrast, coexpression of c-Src restored the inhibitory effect of WNK4 ( -PP1#2 ) on ROMK in the presence of SGK1 and diminished SGK1 induced WNK4 phosphorylation at Ser ( 1196 ) in cells transfected with WNK4 ( -PP1#2 ) ... This suggests the possibility that c-Src regulates the interaction between WNK4 and SGK1 through activating PP1 binding to aa 695-9 thereby decreasing WNK4 phosphorylation and restoring the inhibitory effect of WNK4