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CASP14 — RNF19A

Text-mined interactions from Literome

Zhuang et al., J Biol Chem 2000 : p38 mitogen activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide
Schrantz et al., Mol Biol Cell 2001 (Burkitt Lymphoma) : p38 mediated regulation of an Fas associated death domain protein independent pathway leading to caspase-8 activation during TGFbeta induced apoptosis in human Burkitt lymphoma B cells BL41 ... Indeed, TGFbeta induced activation of p38 and two different inhibitors specific for this mitogen activated protein kinase pathway ( SB203580 and PD169316 ) prevented TGFbeta mediated caspase-8 activation as well as the loss of mitochondrial membrane potential and apoptosis
Sarker et al., J Neurochem 2003 (Pheochromocytoma) : The caspase inhibitor, zVAD, and the mitochondrial pore opening inhibitor, cyclosporine A, blocked anandamide induced cell death but not p38 MAPK/JNK activation, suggesting that activation of these kinases may occur upstream of mitochondrial associated events
Bhattacharyya et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Of foremost interest in the present study was the finding that ASK1/p38 signaling was essential for caspase 8 activation linked to M. avium induced death signaling
Alvarado-Kristensson et al., J Exp Med 2004 (Inflammation) : Consequently, p38-MAPK can directly phosphorylate and inhibit the activities of caspase-8 and caspase-3 and thereby hinder neutrophil apoptosis, and, in so doing, regulate the inflammatory response
Sethi et al., Photochem Photobiol 2004 : However, the caspase-3 and -1 inhibitors did not affect UV-B induced expression of phospho-p38 and -JNK
Hu et al., Crit Care Med 2005 (Sepsis) : In addition, inhibition of p38 mitogen activated protein kinase with SB203580 suppressed apoptosis and caspase-3 activation induced by curcumin ... Thus, activation of p38 mitogen activated protein kinase or an increase in caspase-3 activity appears to contribute to the proapoptotic effect of human neutrophil apoptosis by curcumin
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1 , caspase-3 and caspase-11
Nawaz et al., Toxicological sciences : an official journal of the Society of Toxicology 2006 (Necrosis) : Inhibition of the ERK activator MEK, as well as of p38 , significantly reduced caspase activation and necrosis, whereas c-Jun N-terminal kinase (JNK) inhibition diminished only caspase activity
Gustafsson et al., Mol Pharmacol 2006 (Lymphoma, Mantle-Cell) : Taken together, these results suggest that concurrent ligation of CB(1) and CB(2) with either R ( + ) -MA or Win55 induces apoptosis via a sequence of events in MCL cells : accumulation of ceramide, phosphorylation of p38 , depolarization of the mitochondrial membrane, and caspase activation
Hsu et al., Toxicology 2007 (Osteosarcoma) : This p38 MAPK phosphorylation subsequently activated caspase-3 leading to apoptosis
Miggin et al., Proc Natl Acad Sci U S A 2007 : However, we found that Mal was cleaved by caspase-1 and that inhibition of caspase-1 activity blocked TLR2- and TLR4 mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or TLR7 signaling, which are Mal independent
El Mchichi et al., Cell Death Differ 2007 : Inhibition of p38 activity using either pharmacological inhibitors or dominant negative mutant forms of p38 blocked Mn ( 2+ ) -mediated phosphorylation of MSK1 and blocked subsequent caspase-8 activation
Myatt et al., Oncogene 2008 (Sarcoma, Ewing) : Furthermore, inhibition of p38 ( MAPK ) activity and knockdown of EWS-Fli1 reduced fenretinide induced mitochondrial permeabilization, cytochrome c release, caspase and PARP cleavage, consistent with the hypothesis that p38 ( MAPK ) is critical for activation of the death cascade by fenretinide in ESFT cells
Kim et al., Apoptosis 2008 : In conclusion, ACh prevented the hypoxia induced apoptosis of mouse ES cells by inhibiting the ROS mediated p38 MAPK and JNK activation as well as the regulation of Bcl-2, c-IAPs, and caspase-3
López-Aranda et al., Neurosci Lett 2008 : Expression of sGalphai2 protein in BHK cells led to the production of active form of caspase-3 and activation of p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase 1/2 ( ERK1/2 )
Lu et al., Clin Exp Pharmacol Physiol 2009 (Osteosarcoma) : Desipramine induced caspase 3 activation required p38 MAPK activation
Rana et al., J Trace Elem Med Biol 2008 : Immuno suppressive mechanisms contribute in lead induced apoptosis whereas in the case of mercury, p38 mediated caspase activation regulate apoptosis
Yoon et al., Mol Cancer Res 2009 (MAP Kinase Signaling System) : Activation of p38 mitogen activated protein kinase is required for death receptor independent caspase-8 activation and cell death in response to sphingosine
Boosani et al., Invest Ophthalmol Vis Sci 2009 (Neovascularization, Pathologic) : FAK and p38-MAP kinase dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1 ( IV ) NC1
Supinski et al., Am J Respir Cell Mol Biol 2010 (Sepsis) : Inhibition of p38 with either SB203580 or with a dominant negative p38 construct prevented caspase activation ( P < 0.001 )
Hilchie et al., Nutr Cancer 2010 (Prostatic Neoplasms) : Interestingly, curcumin induced apoptosis was not prevented by p38 MAPK, JNK, or caspase inhibition
Yoshikawa et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : TSA prevented TGF-beta1 induced apoptosis and the activation of caspase-8 and caspase-9 in RPTECs but did not inhibit the TGF-beta1 induced phosphorylation of Smad3 and p38 mitogen activated protein kinase ( MAPK )
Zhai et al., Neurochem Int 2011 (Calcium Signaling) : The above results suggested that SAA could antagonize the cytotoxicity of colchicine in the rat cortical neurons, which may be through inhibition of phosphorylation of JNK and p38 MAPKs, calcium influx, and the activation of caspase-3
Rebola et al., J Neurochem 2011 : The LPS induced increases in phosphorylation of c-jun N-terminal kinase and p38 and activation of caspase 3 were also prevented by SCH58261
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation, while did not affect the degradation of I?Ba, activation of ERK or p38 , and processing of caspase-3 induced by TNF-a
Feng et al., Indian J Exp Biol 2011 : Inhibition of p38MAPK also significantly attenuates caspase-3 and bax protein expressions, but increased significantly bcl-2 expression as determined by Western blot analysis
Chiacchiera et al., Cancer Lett 2012 (Colorectal Neoplasms) : Here we show that inhibition of p38a is followed by TRAIL mediated activation of caspase-8 and FoxO3A dependent HER3 upregulation with consequent overactivation of the MEK-ERK1/2 survival pathway
Arango et al., Biochem Pharmacol 2012 : Apigenin induced DNA damage was mediated by p38 and protein kinase C-delta ( PKCd ), yet was independent of reactive oxygen species or caspase activity