UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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ADRB2 — CXCL12

Pathways - manually collected, often from reviews:

BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: G-alpha-s/GTP complex (GNAS) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) (modification, collaborate)
BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GTP/G-alpha-S complex (GNAS) (modification, collaborate)
BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta chrebp regulation by carbohydrates and camp: GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta ÃŸ-arrestins in gpcr desensitization: ligand/GPCR complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → G-protein Receptor (HTR2C/ADRA1B/AGTR2/CHRM1/CCR5/PTGER1/P2RY2/CCR3/EDNRB/EDNRA/CXCR4/FPR1/ADRB2) (degradation, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: B2AR/G-alpha-s/G-gamma/G-beta/GDP complex (ADRB2-GNAS-GNGT1-GNB1) → Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: B2AR/G-alpha-s/G-gamma/G-beta/GDP complex (ADRB2-GNAS-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → G-alpha-s/GTP complex (GNAS) (modification, collaborate)
BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta activation of camp-dependent protein kinase pka: G-alpha-s/GTP complex (GNAS) → G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta roles of ÃŸ arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) (modification, collaborate)
BioCarta roles of ÃŸ arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → G-alpha-s/GTP complex (GNAS) (modification, collaborate)
BioCarta roles of ÃŸ arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta roles of ÃŸ arrestin dependent recruitment of src kinases in gpcr signaling: GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: Ligand/B2AR/G-gamma/G-beta/PKA/CFTR/Ezrin/EBP50/EBP50 complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B-VIL2-SLC9A3R1) → PKA/CFTR/Ezrin/EBP500/EBP50 complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B-CFTR-VIL2-SLC9A3R1) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: Ligand/B2AR/G-gamma/G-beta/PKA/CFTR/Ezrin/EBP50/EBP50 complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B-VIL2-SLC9A3R1) → CFTR (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: Ligand/B2AR/G-gamma/G-beta/PKA/CFTR/Ezrin/EBP50/EBP50 complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B-VIL2-SLC9A3R1) → Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: PKA/CFTR/Ezrin/EBP500/EBP50 complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B-CFTR-VIL2-SLC9A3R1) → Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: CFTR → Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
BioCarta cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway: Ligand/B2AR/G-gamma/G-beta complex (ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) → None (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, activates)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, activates)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: g-gamma/g-beta complex (GNGT1-GNB1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1) (modification, collaborate)
BioCarta role of ÃŸ-arrestins in the activation and targeting of map kinases: Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Arrestin (ARRB1) (modification, collaborate)
BioCarta corticosteroids and cardioprotection: G-gamma/G-beta/GTP complex (GNGT1-GNB1) → Ligand/B2AR/G-alpha-S complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ADRB2-GNAS) (modification, collaborate)
BioCarta corticosteroids and cardioprotection: B2AR/G-alpha-s/G-gamma/G-beta/GDP complex (ADRB2-GNAS-GNGT1-GNB1) → Ligand/B2AR/G-alpha-S complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ADRB2-GNAS) (modification, collaborate)
BioCarta corticosteroids and cardioprotection: B2AR/G-alpha-s/G-gamma/G-beta/GDP complex (ADRB2-GNAS-GNGT1-GNB1) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)
BioCarta corticosteroids and cardioprotection: Ligand/B2AR/G-alpha-S complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ADRB2-GNAS) → Ligand (CCL4/EDN1//AGT/CCL11/CXCL12/F2) (modification, collaborate)