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MAPK10 — MAPK3

Text-mined interactions from Literome

Khan et al., J Biol Chem 2000 : These data demonstrate that incubation of macrophages with alpha1 : SRARKQAASIKVAVSADR, but not intact laminin-1, triggers protein kinase C-dependent activation of MAPK ( erk1/2 ), leading to the up-regulation of proteinase expression
Raggatt et al., J Endocrinol 2000 : CT treatment of cells expressing the insert -ve, but not insert +ve hCTR, induced the phosphorylation of Erk1/2 MAPK , which persisted for at least 72 h. Treatment of cells expressing the insert -ve hCTR with the MAPK kinase ( MEK ) inhibitor, PD-98059, inhibited the phosphorylation of Erk1/2 and abrogated the growth inhibitory effects of salmon CT, the accumulation of cells in G2, and the associated induction of p21 ( WAF1/CIP1 )
Blaschke et al., Biochem Biophys Res Commun 2002 (Anoxia) : Hypoxia induced a time dependent activation of ERK 1/2 and p38 MAPK activation in human VSMCs, which were completely abolished by PD98059 or SB203580, respectively
Choi et al., Infect Immun 2003 : Thus, we examined whether H. pylori induced extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) and p38 MAPK activation affects gastric epithelial cell apoptosis and bcl-2 family gene expression, especially in relation to the cagA status of an H. pylori strain
Sawamura et al., J Neurochem 2003 (Niemann-Pick Diseases) : In CT43 cells, mitogen activated protein ( MAP ) kinase Erk1/2 was activated and the specific MAPK inhibitor, PD98059, attenuated the hyperphosphorylation of tau
Frank et al., J Biol Chem 2003 : The inhibitory effect of TGF-beta1 on sodium uptake and alphaENaC expression in ATII cells was mediated by activation of the MAPK , ERK1/2
Sorensen et al., Mol Pharmacol 2003 : Comparison of the intracellular signaling pathways of glial PAR-1, LPA, and S1P receptors indicates that each receptor class activates multiple downstream signaling pathways, including Gq/11 directed inositol lipid/Ca2+ signaling, Gi/o activation of mitogen activated protein kinases ( MAPK ) ( extracellular signal regulated kinase 1/2 and stress activated protein kinase/c-jun N-terminal kinase, but not p38 ), and activation of Rho pathways
Cantó et al., J Biol Chem 2004 : HRG also stimulated the activity of p70S6K, p38MAPK , and p42/p44MAPK and inhibition of p42/p44MAPK partially repressed HRG action on glucose uptake
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : ERK-1/2 inhibition or IL-10 neutralization restores CD40 induced p38MAPK activation and parasite killing in macrophages and the BALB/c mouse, a susceptible host
Couty et al., Biol Cell 2004 (Disease Models, Animal...) : In in vitro systems, HHV-8-GPCR signals via multiple transduction pathways including, activation of phospholipase C and PKC, inhibition of adenylyl cyclase, activation of nuclear factor-kappaB ; activation PI 3-kinase, p42/44 MAPK and Akt/PKB, and activation of JNK/SAPK, p38 MAPK and RAFTK
Hers et al., Biochem J 2005 : The effect of insulin on phosphorylation of both these sites required the activation of PI3K and the MAPKs ( mitogen activated protein kinases ) ERK1/2 ( extracellular-signal regulated kinase 1 and 2 ), but not the activation of mTOR ( mammalian target of rapamycin ) /p70S6 kinase, JNK ( c-Jun N-terminal kinase ) or p38MAPK
Jiang et al., J Mol Neurosci 2005 (MAP Kinase Signaling System) : A selective MAPK kinase inhibitor, U0126, blocked the H2O2 induced phosphorylation of Erk1/2 ( extracellular signal regulated kinase ) in PC12 cells and increased the levels of active caspase-3 in M-M17-26 under serum withdrawal or H2O2 treatment
Hughes-Fulford et al., Cell Signal 2005 : Extracellular signal regulated kinase-2 ( ERK2 ) pathway was found to be significantly activated greater than seven-fold within 30 min ; however, there was little activation of ERK-1 and no activation of JNK or p38 MAPK
Shin et al., Biol Pharm Bull 2005 : We show that among the mitogen activated protein kinase family activation of phosphorylation of extra cellular signal regulated kinase 1/2 ( ERK1/2, p44/42 ) and p38, but not c-jun NH2-terminal kinase is inhibited
Jacquel et al., Oncogene 2006 (Leukemia) : Differentiation of K562 cells by the combination of PMA and SB required Erk1/2 activation, a threshold of JNK activation and p38 MAPK inhibition
Ohkawara et al., Eur J Pharmacol 2005 : Astrapterocarpan inhibited PDGF-BB induced phosphorylation of extracellular signal regulated kinase 1/2 ( ERIC1/2 ) mitogen activated protein ( MAP ) kinase
Eitenmüller et al., Circ Res 2006 (Arterial Occlusive Diseases) : The activities of Ras and ERK-1 , -2 were markedly increased in collateral vessels of the shunt experiment, and infusions of L-NAME and L-NNA strongly inhibited MAPK activity as well as shunt induced arteriogenesis
Romano et al., Endocrinology 2006 : In the present study, we focused on the involvement of the phosphoinositide 3-kinase (PI3K)/Akt pathway in the MAPK ERK-1/2 regulation and PRL secretion in pituitary cells
Rahman et al., J Immunol 2006 (Asthma...) : IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells : role of MAPK ( Erk1/2 , JNK, and p38 ) pathways
Koch et al., Respir Med 2007 (Asthma) : In conclusion, ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and ( 2 ) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma
Yano et al., Circ Res 2007 (Inflammation) : Statins activate peroxisome proliferator activated receptor gamma through extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase dependent cyclooxygenase-2 expression in macrophages
Suzuki et al., J Cell Physiol 2008 (Hemorrhage) : Two hrs thereafter, Kupffer cells and SMPhi production of IL-6, TNF-alpha, and IL-10, activation of MAPK ( p38, ERK-1/2 , and JNK ), and transcription factors ( NF-kappaB and AP-1 ) were determined
Hasan et al., Circ Res 2008 : Inhibiting hemin induced ERK-1/2 activation by U0126 ( MAPK-inhibitor ), the antioxidant N-acetyl cysteine, the NADPH oxidase inhibitors apocynin and diphenyleneiodonium chloride, the superoxide scavenger tiron, or tricarbonyldichlororuthenium ( II ) -dimer ( carbon-monoxide donor ; CORM-2 ) blocked hemin induced Egr-1 expression
Rivas et al., Exp Cell Res 2008 (Carcinoma, Ductal, Breast...) : A TNF alpha-specific mutein selectively binding to TNFR1 induced p42/p44 MAPK , JNK, Akt activation, NF-kappa B transcriptional activation and cell proliferation, just like wild-type TNF alpha, while a mutein selective for TNFR2 induced only p42/p44 MAPK activation
Suzuki et al., Cytokine 2008 (Hemorrhage...) : Two hours thereafter, T cell production of IL-2 and IFN-gamma and activation of MAPK ( p38, ERK-1/2 and JNK ) were determined
Matsubayashi et al., J Pathol 2008 (Breast Neoplasms...) : In addition, GRK4-over expressing cells activated the mitogen activated protein kinase ( MAPK ) mediated by ERK 1/2 and JNK phosphorylation in breast cancer derived cell lines
Chandra et al., Clin Exp Immunol 2008 (Leishmaniasis, Visceral...) : Parasites also modulated the TLR2 stimulated mitogen activated protein kinase ( MAPK ) pathway by suppressing MAPK P(38) phosphorylation and activating extracellular regulated kinase (ERK)1/2 phosphorylation
Salamat et al., Dev Comp Immunol 2009 : These results suggest that PKC induced activation of the mitogen activated protein kinase , ERK1/2 , is involved in cell division in the APO
Kozono et al., Biochem Biophys Res Commun 2010 : CP55940 ( CB1/CB2 agonist ) induced phosphorylation of the extracellular regulated kinases (ERK) 1/2 , p38 mitogen activated protein kinase ( p38MAPK ), and Akt in HGFs. Wound closure by CP55940 in an in-vitro scratch assay was significantly suppressed by inhibitors of MAP kinase kinase ( MEK ), p38MAPK , and phosphoinositol 3-kinase (PI3-K)
McClelland et al., Proc Natl Acad Sci U S A 2010 (MAP Kinase Signaling System) : RNA interference and biochemical experiments support the model that ephrin-B3 regulates synapse density by directly binding to Erk1/2 to inhibit postsynaptic Ras/mitogen activated protein kinase signaling
Krug et al., Hypertension 2010 : MR blockade and extracellular signal regulated kinase 1/2 mitogen activated protein kinase inhibition prevent age associated increases of transforming growth factor-beta, intercellular adhesion molecule 1, and procollagen 1
Bocelli-Tyndall et al., Arthritis Rheum 2010 : Both MAPK/ERK-1/2 and phosphatidylinositol 3-kinase/Akt controlled cell proliferation and HLA-DR expression, but only MAPK/ERK-1/2 controlled the induction of the class II MHC transcription activator protein CIITA, the major determinant of HLA-DR transcription
Jeong et al., J Pharm Pharmacol 2011 (MAP Kinase Signaling System) : Additionally, PD-98058 ( 10 µm ), a selective ERK 1/2 MAPK inhibitor, and SB-203580 ( 10 µm ), a selective p38 MAPK inhibitor , significantly reduced the MIGB induced contraction of ileal longitudinal muscles
Siddhanti et al., Endocrinology 1995 : We found that PMA stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk ( ERK1 ) and p42mapk ( ERK2 ) and activation of Raf-1, MKK, and MAPK in these cells ... FSK treatment of osteoblasts, which raised intracellular cAMP levels and inhibited DNA synthesis, blocked PKC stimulated tyrosine phosphorylation of p44mapk ( ERK1 ) and p42mapk ( ERK2 ) as well as inhibited PKC stimulated MAPK and Raf-1 activities
Kumar et al., J Biol Chem 1998 : These results show that IL-1beta- or TNF induced LDL receptor expression requires ERK-1/2 activation, that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells
Ainbinder et al., Recept Signal Transduct 1997 (Carcinoma, Hepatocellular...) : Evidence is presented that stimulation of c-fos transcription by MC involves a signal transduction pathway, which includes activation of the small G protein Ras, Raf-1 kinase, and the mitogen activated protein ( MAP ) kinases , ERK1 and ERK2
Lundberg et al., J Mol Cell Cardiol 1998 : Platelet derived growth factor BB ( PDGF BB ) activation of the mitogen activated protein kinases ( MAPK ), ERK1 and ERK2, has been shown to be necessary for mitogen stimulated proliferation, but its role in regulating cell migration and its relationship to other chemotactic signaling events, such as CamKII activation, has not been defined