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MAPK3 — MEFV
Text-mined interactions from Literome
Puri et al., Genes Dev 2000
(Rhabdomyosarcoma) :
Enforced induction of p38
MAPK by an activated MAPK kinase 6 ( MKK6EE ) restored MyoD function and
enhanced MEF2 activity in RMS deficient for p38 MAPK activation, leading to growth arrest and terminal differentiation
Han et al., Trends Cardiovasc Med 2000
(Cardiomegaly) :
Regulation of
MEF2 by p38
MAPK and its implication in cardiomyocyte biology
Wu et al., J Clin Invest 2002
(Myotonia Congenita) :
These findings suggest that the combined effects of class II HDAC deficiency and p38
MAPK activation
lead to potent upregulation of
MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Burton et al., Brain Res Mol Brain Res 2002
(Alzheimer Disease...) :
Also, expression of hAPPwt mediated an increase in MEF2 DNA binding affinity that correlated with p38
MAPK dependent trans-activation of a
MEF2-responsive reporter gene ... A model of anti-apoptotic APP signaling is proposed where APP mediates p38
MAPK dependent phosphorylation and activation of
MEF2
Yin et al., Frontiers in physiology 2012
:
Following the first demonstration that mitogen activated protein kinase p38 ( p38
MAPK ) directly phosphorylates and
activates MEF2 to promote neuronal survival, several other kinase regulators of MEF2s have been identified
Scott et al., J Biol Chem 1995
:
This was manifest by the finding that in the
presence of
MEF , molar equivalents of MEK to MAPK were sufficient to produce fully phosphorylated ( 2.1 +/- 0.4 mol/mol ; S.D., n = 3 ) and activated
MAPK