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MTOR — WNT1
Text-mined interactions from Literome
Rosner et al., Mutat Res 2008
(Alzheimer Disease...) :
Recently, it has been recognized that
mTOR is
regulated by TNF-alpha and
Wnt , both of which have been shown to play critical roles in the development of many human neoplasias
Fujishita et al., Proc Natl Acad Sci U S A 2008
(Adenoma...) :
These results suggest that the
Wnt signaling
contributes to
mTORC1 activation through the increased level of mTOR and that the activation plays important roles in the intestinal polyp formation and growth
Ma et al., J Neurosci 2011
(Wnt Signaling Pathway) :
Synaptic stimulation of
mTOR is
mediated by
Wnt signaling and regulation of glycogen synthetase kinase-3
Liu et al., J Biol Chem 2012
(Diabetes Mellitus, Type 2...) :
Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished
Wnt dependent
mTORC1 activity and enhanced expression of brown adipose tissue PGC1-a and UCP1
Kumar et al., Carcinogenesis 2012
(Colonic Neoplasms...) :
Further, a combination regime of SDs and low-dose rapamycin decreased visible polyps in Apc ( Min/+ ) mice and reduced the levels of
Wnt target gene expression and
mTOR target
activation