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MMP28 — PIK3R1
Text-mined interactions from Literome
Fukaya et al., Oncol Rep 2005
(Lung Neoplasms...) :
Inhibition of
PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt,
resulted in suppression of
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Redondo-Muñoz et al., Blood 2006
(Leukemia, B-Cell...) :
Moreover, B-CLL cells formed podosomes upon adhesion to FN-H89, VCAM-1, or fibronectin
; MMP-9 localized to podosomes in a
PI3-K dependent manner and degraded a fibronectin/gelatin matrix
Roztocil et al., J Surg Res 2007
:
Migration assays were performed in the presence of K with and without the plasmin inhibitors ( aprotinin and -aminocaproic acid ), the Galphai inhibitor Pertussis toxin, the
MMP inhibitor ( GM6001 ), the
PI3-K inhibitors , Wortmannin and LY294002, and the MAPK inhibitors PD98089 ( MEK1 inhibitor ) and SB203580 ( p38 ( MAPK ) inhibitor )
Kim et al., Biochim Biophys Acta 2010
(Prostatic Neoplasms) :
Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing
MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells