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CIITA — MAPK4

Text-mined interactions from Literome

Pennini et al., J Immunol 2006 (MAP Kinase Signaling System) : Thus, CIITA expression was inhibited by TLR2 induced MAPK signaling that caused histone hypoacetylation at CIITA pIV and suppression of CIITA transcription
Yao et al., J Immunol 2006 (MAP Kinase Signaling System) : ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages ... In this study, we report that both constitutive and IFN-gamma-inducible expression of CIITA in mouse bone marrow derived dendritic cells ( DC ) and macrophages, respectively, are regulated by MAPK signals ... In DC, the inhibitory effect of LPS on CIITA expression was prevented by MyD88 deficiency or pharmacological MAPK inhibitors specific for MEK ( U0126 ) and p38 ( SB203580 ), but not JNK ( SP600125 )
Hardy et al., Immunology 2009 : Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Bocelli-Tyndall et al., Arthritis Rheum 2010 : Both MAPK/ERK-1/2 and phosphatidylinositol 3-kinase/Akt controlled cell proliferation and HLA-DR expression, but only MAPK/ERK-1/2 controlled the induction of the class II MHC transcription activator protein CIITA , the major determinant of HLA-DR transcription