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MAPK7 — SYN1
Text-mined interactions from Literome
Jovanovic et al., Nat Neurosci 2000
(MAP Kinase Signaling System...) :
In a synaptosomal preparation, brain derived neurotrophic factor (BDNF) increased
mitogen activated protein ( MAP ) kinase dependent
synapsin I phosphorylation and acutely facilitated evoked glutamate release
Chin et al., J Neurosci 2002
(Synaptic Transmission) :
Treatment of pleural-pedal ganglia with TGF-beta1 for 5 min activated mitogen activated protein kinase ( MAPK ) and stimulated the phosphorylation of
synapsin in a
MAPK dependent manner
Giachello et al., J Cell Sci 2010
:
However, the physiological role of
MAPK/Erk dependent
synapsin phosphorylation in regulating synaptic formation and function is poorly understood ... Our findings show that
MAPK/Erk dependent
synapsin phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity, indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target