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AGTR2 — IL8

Pathways - manually collected, often from reviews:

• Reactome Reaction: AGTR2 → IL8 (reaction) Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994

Text-mined interactions from Literome

Schmeisser et al., Biochem Biophys Res Commun 2004 : AngII induced upregulation of IL-8 and MCP-1 protein and RNA in monocytes was inhibited by the AT1R-blocker losartan, but not by the AT2R-blocker PD 123.319
Hochart et al., Br J Haematol 2006 (Bacterial Infections...) : Proinflammatory cytokines tumour necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6 and IL-1beta release were subsequently measured by enzyme linked immunosorbent assay at 6 h, and nuclear translocation of the proinflammatory NF-kappaB was assessed at 2 h. Treatment with pharmacological doses of LMWH and UFH significantly attenuated LPS induced production of TNF-alpha, IL-8 , IL-6 and IL-1beta as well as NF-kappaB translocation
van Meijl et al., Mol Nutr Food Res 2010 (Insulin Resistance) : After 24 h, glutamine inhibited IL-8 production significantly ( p < 0.05 ) at 2 , 5 and 10 mM ( to 82, 73 and 72 % of control ), whereas leucine reduced IL-8 production significantly only at 10 mM ( 66 % ) and proline at 5 and 10 mM ( 71 and 52 % )
Gao et al., Planta Med 1997 : T2a-T2d induced human monocytes to produce interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in vitro