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ATG13 — MTOR

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1) (modification, collaborate)
  Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1) (modification, collaborate)
  Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1) → ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1) (modification, collaborate)
  Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways PI3K-AKT-mTOR signaling pathway and therapeutic opportunities: Complex of RPTOR-MTOR → Complex of RB1CC1-ULK1-ATG13 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: ATG13 — MTOR (unknown, -) Hosokawa et al., Mol Biol Cell 2009
• IRef Innatedb Interaction: ATG13 — MTOR (unknown, -) Jung et al., Mol Biol Cell 2009

Text-mined interactions from Literome

Jung et al., Mol Biol Cell 2009 : ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery ... These findings demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling
Ikeda et al., J Pharmacol Sci 2013 (Adrenal Gland Neoplasms...) : Indeed, direct mTORC1 inhibition initiates ULK1/2 autophosphorylation and subsequent Atg13 and FIP200 phosphorylation, inducing autophagy
Wang et al., J Ethnopharmacol 2013 (Ischemic Attack, Transient...) : HLJDD also notably elevated the levels of microtubule associated protein1 light chain 3 ( LC3 ), Beclin-1, and other autophagy related genes ( Atgs ) , promoted the activation of extracellular signal regulated kinases ( ERK ), protein kinase B ( Akt ), 3-phosphoinositide dependent kinase ( PDK1 ), and inhibited the activation of mammalian target of rapamycin (mTOR) , c-Jun N-terminal protein kinases (JNK), p38, phosphatase and tensin homolog (PTEN)