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AGTR1 — PTGS2
Text-mined interactions from Literome
Höcherl et al., Pflugers Arch 2001
:
Renocortical expression of renin and of
cyclooxygenase-2 in
response to angiotensin II
AT1 receptor blockade is closely coordinated but not causally linked
Zhang et al., Proc Natl Acad Sci U S A 2006
:
In summary, these results demonstrate that macula densa
COX-2 expression is oppositely
regulated by
AT(1) and AT(2) receptors and suggest that AT(2) receptor mediated cortical COX-2 elevation may mediate physiologic effects that modulate AT(1) mediated responses
Morinelli et al., Biochim Biophys Acta 2008
:
These results demonstrate that inhibiting the internalization of the AT1AR results in a loss of ability of Angiotensin II to increase the protein expression of COX-2, thus supporting previous work showing a relationship between
AT1AR nuclear localization and
activation of
COX-2 gene expression
Pham et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
COX-2 promoter
activation by
AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells
Jensen et al., American journal of physiology. Renal physiology 2010
(Reperfusion Injury) :
Therefore, we speculated whether the
effects of
AT1R blockade on V2R and the vasopressin regulated pathway are attributable to attenuated
COX-2 induction
Lemos et al., PloS one 2012
:
Enalapril, losartan, indomethacin, furegrelate, the selective COX-2 inhibitor NS 398, superoxide dismutase and the NADPH oxidase inhibitor apocynin reverted HgCl ( 2 ) effects on the reactivity to phenylephrine,
COX-2 protein expression was increased, and
AT1 expression
reduced
Gonzalez et al., Hypertension 2013
(MAP Kinase Signaling System) :
Importantly, rat recombinant prorenin upregulated
COX-2 expression in the
presence of
AT(1)R blockade
Morinelli et al., Am J Physiol Cell Physiol 2013
:
Activation of the
angiotensin type 1A receptor (AT1AR) in rat aorta vascular smooth muscle cells ( RASMC )
results in increased synthesis of the proinflammatory enzyme
cyclooxygenase-2 (COX-2)
Mangat et al., J Clin Invest 1997
(Hypercalcemia) :
To determine if
AT1 angiotensin II receptor activation was
involved in the stimulation of cPLA2 and
PGHS-2 in hypercalcemia, we treated rats with the AT1 receptor antagonist, losartan ... To determine if AT1
angiotensin II receptor activation was
involved in the stimulation of cPLA2 and
PGHS-2 in hypercalcemia, we treated rats with the AT1 receptor antagonist, losartan