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CIB1 — FOXO3
Text-mined interactions from Literome
Essaghir et al., J Biol Chem 2009
:
Conversely, ectopic
FOXO3 activation blocked the proliferation of fibroblasts and
induced the expression of FOXO1, FOXO4, and
p27-KIP1
Chen et al., PloS one 2010
(Prostatic Neoplasms) :
The inhibition of PI3K/AKT pathway
induced FOXO transcriptional activity resulting in induction of Bim, TRAIL,
p27/KIP1 , DR4 and DR5, and inhibition of cyclin D1
Qi et al., BMC cancer 2011
(Colonic Neoplasms) :
Thus, the
FOXO3-p53 ( mut ) complex
leads to elevated
p27kip1 expression and promotes cell cycle arrest
Qi et al., J Biol Chem 2013
(Colonic Neoplasms) :
In parallel, LD-dependent loss of
FOXO3 led to its dissociation from the promoter and decreased expression of the cell cycle inhibitor
p27kip1