Gene interactions and pathways from curated databases and text-mining

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MAPK1 — MCL1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Leuenroth et al., Surgery 2000 : Western blot analysis confirmed that the inhibition of p38 MAPK led to a significant decrease in Mcl-1 expression
Chetoui et al., Mol Cancer Res 2008 (Melanoma) : Our results further show that the expression of Mcl-1 in melanoma cells is regulated by the mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) and not by phosphatidylinositol 3-kinase/AKT signaling pathway
Dyugovskaya et al., Journal of translational medicine 2012 (Anoxia...) : Specifically, the balance between pro-apoptotic Bax and anti-apoptotic Mcl-1 protein expression, and the potential involvement of p38MAPK and ERK1/2 signaling pathways in the control of Mcl-1 expression were investigated ... Accordingly, both ERK and p38MAPK inhibitors attenuated the IH-induced Mcl-1 increase