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CASP14 — PAK1

Text-mined interactions from Literome

Yoshii et al., Mol Cell Biol 2001 : Finally, a preferential caspase inhibitor, Z-Asp-CH2-DCB, strongly blocked the alphaPIX ( Delta CH ) -enhanced apoptosis in cells treated with B ( a ) P but did not block PAK1/JNK1 activation
Basak et al., J Biol Chem 2005 (MAP Kinase Signaling System) : NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1 mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide stimulated macrophages ... Most important, we observed a role of Rac1/PAK1 signaling in activation of caspase-1 , which is necessary for maturation of pro-IL-1beta ... Taken together, these results suggested a role of PAK1 induced phosphorylation of caspase-1 at Ser376 in activation of caspase-1
Menard et al., Neoplasia (New York, N.Y.) 2005 (Breast Neoplasms...) : PAK1 dependent regulation of anoikis is likely to occur early in the apoptotic cascade as expression of dominant negative PAK1 increased the cleavage of the upstream caspase 9, while constitutively active PAK1 inhibited caspase 9 activation
Ong et al., Proc Natl Acad Sci U S A 2011 (Lymphatic Metastasis...) : Dual inhibition of PAK1 and X chromosome linked inhibitor of apoptosis efficiently increased effector caspase activation and apoptosis of NSCLC cells