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CAPN1 — PDCD7
Text-mined interactions from Literome
Rami et al., Brain Res 2000
(Brain Ischemia...) :
We tested a potential
role for
calpain in the
programmed cell death under ischemic conditions and found that calpain is ( 1 ) activated at a time preceding morphological changes, DNA fragmentation and death, ( 2 ) that calpain is translocated to the nucleus before DNA laddering, ( 3 ) pretreatment with caspase inhibitors and/or calpain inhibitors block not only the proteolytic actions of the enzyme, but also the cell death process itself in the CA1 subfield after transient global ischemia in a synergistic manner
Wales et al., Gene Ther 2008
(Parkinson Disease) :
ICP10PK inhibits
calpain dependent release of apoptosis inducing factor and
programmed cell death in response to the toxin MPP+
Suryakumar et al., J Cardiovasc Pharmacol 2010
(Cardiomegaly...) :
Because beta3 integrin contributes to cardioprotective signaling, these studies indicate that the loss of specific integrin function could be a key mechanism for
calpain mediated
programmed cell death of cardiomyocytes in PO myocardium
Dong et al., Cancer Res 2010
(Prostatic Neoplasms) :
Combination therapy significantly elevated SSB level, ?-H2AX foci formation, and poly ( ADP-ribosylation ) of PARP-1, which were associated with ATP loss and induction of
ยต-calpain induced
programmed cell death
Perez-Pinzon et al., J Cereb Blood Flow Metab 2012
(Nerve Degeneration) :
Oxidative stress and Ca ( 2+ ) -activated
calpain protease activities also
promote apoptosis and other forms of
programmed cell death , primarily through modification of proteins and lipids present at the outer membrane, causing release of proapoptotic mitochondrial proteins, which initiate caspase dependent and caspase independent forms of cell death