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HRAS — IL6

Text-mined interactions from Literome

Nakajima et al., Proc Natl Acad Sci U S A 1993 : We observed that coexpression of oncogenic p21ras stimulated the transactivating activity of NF-IL6 and induced phosphorylation of Thr-235 located just N-terminal to the DNA binding domain of NF-IL6
Nakajima et al., Mol Cell Biol 1993 (Carcinoma, Hepatocellular...) : Despite the similarity in the structure between the JRE-IL6 element and the polyomavirus enhancer PyPEA3, composed of an EBS and an AP1 binding site and known to be activated by a variety of oncogene signals, JRE-IL6 could not be activated by activated Ha-Ras , Raf-1, or 12-O-tetradecanoylphorbol-13-acetate
Neumann et al., Eur J Immunol 1996 (Multiple Myeloma) : Like many other cytokines and growth factors, interleukin-6 (IL-6) activates p21ras
Berger et al., Blood 1997 (Multiple Myeloma) : IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal transducing subunit gp130, the gp130 associated protein tyrosine kinases Jak1, Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen activated protein kinase Erk2, and accumulation of GTP bound p21ras