Gene interactions and pathways from curated databases and text-mining

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CASP9 — CCR7

Text-mined interactions from Literome

Madesh et al., J Cell Biol 2001 (Carcinoma, Hepatocellular...) : O2* -- induced CCR was followed by caspase activation and execution of apoptosis
Rafei et al., J Immunol 2009 (Arthritis, Experimental...) : However, CCR2 dependent calcium mobilization, BAX induction and caspase-3 activation followed by cell death was observed
Xu et al., PloS one 2012 (Carcinoma, Non-Small-Cell Lung...) : Western blot and real-time PCR assays indicated that activation of CCR7 significantly caused upregulation of anti-apoptotic bcl-2 and downregulation of pro-apoptotic bax and caspase-3 , but not p53, at both protein and mRNA levels