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DST — SPAG8

Text-mined interactions from Literome

Guo et al., Toxicol Lett 2012 : BPA inhibited human and rat 11ß-HSD1 activities with the half maximal inhibitory concentrations ( IC ( 50 ) s ) of 14.81±0.06µM ( mean±SEM ) for human and 19.39±0.09µM for rat enzyme, respectively ... BPA inhibited rat 11ß-HSD1 activity in intact rat Leydig cells
Wang et al., Int J Obes Relat Metab Disord 2013 : The effects of BPA ( 10?nM, 1?µM, and 80?µM ) on 11ß-HSD1, PPAR-? and LPL mRNA expression, and 11ß-HSD1 enzymatic activity in adipose tissue and adipocytes were assessed in vitro ... BPA , at environmentally relevant levels, increased the mRNA expression and enzymatic activity of 11ß-HSD1 by acting upon a GC receptor, which may lead to the acceleration of adipogenesis