◀ Back to MMP2
MMP2 — TIMP4
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TIMP4
—
MMP2
(direct interaction, pull down)
Bigg et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
TIMP4
—
MMP2
(direct interaction, pull down)
Kai et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
TIMP4
—
MMP2
(in vitro)
Kai et al., J Biol Chem 2002*, Bigg et al., J Biol Chem 1997*
-
IRef Matrixdb Interaction:
TIMP4
—
MMP2
(direct interaction, surface plasmon resonance)
Troeberg et al., Biochemistry 2002*
-
IRef Matrixdb Interaction:
TIMP4
—
MMP2
(enzymatic reaction, enzymatic study)
Troeberg et al., Biochemistry 2002*
-
IRef Ophid Interaction:
TIMP4
—
MMP2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Hernandez-Barrantes et al., Biochem Biophys Res Commun 2001
:
Differential
roles of
TIMP-4 and TIMP-2 in
pro-MMP-2 activation by MT1-MMP ...
TIMP-4 , unlike TIMP-2, does not
promote pro-MMP-2 activation by MT1-MMP
Schulze et al., Circulation 2003
(Acute Disease...) :
Loss of
TIMP-4 from the cardiac myocyte
leads to an increase in net myocardial
MMP activity that contributes to acute myocardial stunning injury
Camp et al., J Hypertens 2003
(Glomerulosclerosis, Focal Segmental...) :
The increased levels of
TIMP-4 in the medulla may
inhibit the collagenolytic activity of
MMP but is unable to inhibit the elastinolytic activity
Fernández et al., Biochem Biophys Res Commun 2006
:
Despite the importance of MMP activity in the regulation of angiogenesis, relatively little is known about the role of
TIMP-4 , the most recently discovered endogenous
MMP inhibitor , in modulating neovascularization
Beeri et al., Circulation 2007
(Mitral Valve Insufficiency...) :
With repair,
matrix metalloproteinase-2 decreased to < or = 50 % that without repair in remote and border zones at 3 months, and the matrix metalloproteinase inhibitor
TIMP-4 increased dramatically