Wesemann et al., J Immunol 2002
:
We conclude that SOCS-1 inhibits cytokine induced CD40 expression by blocking IFN-gamma mediated STAT-1alpha activation, which also then results in suppression of IFN-gamma induced TNF-alpha secretion and subsequent NF-kappaB activation
Zhou et al., Int Immunopharmacol 2004
:
Trapidil inhibits monocyte CD40 expression by preventing IFN-gamma induced STAT1 S727 phosphorylation ... Collectively, our results indicate that phosphorylation of STAT1 at the Ser727 site enhances CD40 transcription and that Trapidil might be used as a selective inhibitor that could differentially modulate STAT1 target genes
Qin et al., Blood 2005
:
LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia ... Blocking IFN-beta induced activation of STAT-1alpha by IFN-beta neutralizing antibody reduces LPS induced CD40 gene expression
Qin et al., FASEB J 2006
:
The ectopic expression of SOCS-1 abrogates IFN-beta mediated STAT-1alpha activation and inhibits IFN-beta induced CD40 expression
Lee et al., J Leukoc Biol 2007
:
Simvastatin inhibits IFN-gamma induced CD40 gene expression by suppressing STAT-1alpha ... IFN-gamma induced CD40 expression involves activation of STAT-1alpha as well as NF-kappaB activation through an autocrine response to IFN-gamma induced TNF-alpha production
Lam et al., J Biol Chem 2007
:
Blocking the activity of Akt demonstrated a crucial role for Akt in translocation of STAT-1alpha and NF-kappaB to the nucleus and activation of the CD40 promoter
Rezai-Zadeh et al., Journal of neuroinflammation 2008
(Encephalitis) :
Apigenin and luteolin modulate microglial activation via inhibition of STAT1 induced CD40 expression