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FGFR3 — STAT1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Hprd Interaction:
FGFR3
—
STAT1
(in vivo)
Hart et al., Oncogene 2000, Hart et al., Mol Biol Cell 2001, Uddin et al., J Biol Chem 2002, Dimberg et al., Blood 2003*, Deb et al., J Immunol 2003, DeVries et al., J Biol Chem 2004, Wen et al., Cell 1995*, Quelle et al., J Biol Chem 1995, Shuai et al., Science 1993
-
IRef Hprd Interaction:
FGFR3
—
STAT1
(in vitro)
Hart et al., Oncogene 2000, Hart et al., Mol Biol Cell 2001, Uddin et al., J Biol Chem 2002, Dimberg et al., Blood 2003*, Deb et al., J Immunol 2003, DeVries et al., J Biol Chem 2004, Wen et al., Cell 1995*, Quelle et al., J Biol Chem 1995, Shuai et al., Science 1993
Text-mined interactions from Literome
Britto et al., Cleft Palate Craniofac J 2002
(Acrocephalosyndactylia...) :
In addition, the immunolocalization of the ligand FGFs 2, 4, and 7 was undertaken together with the intracellular transcription factor
STAT1 , which is
activated by
FGFR signaling
Nakajima et al., Endocrinology 2003
(Femoral Fractures) :
Furthermore, FGFR3, STAT1, and p21 exhibited a similar temporal expression profile, suggesting that
FGFR3 mediated
STAT1-p21 signaling plays a role in fracture repair
Citores et al., J Cell Physiol 2007
(Breast Neoplasms) :
Both FGFR1 and FGFR2 induced strong phosphorylation of STAT1 causing redistribution of the Golgi apparatus, while
FGFR3 and FGFR4
induced less phosphorylation of
STAT1 and little or no redistribution of the Golgi apparatus
Harada et al., Bone 2007
(Dwarfism) :
Here we reveal that phospholipase C gamma ( PLCgamma ) mediates
FGFR3 induced
STAT1 activation ... Both PLCgamma and STAT1 were activated by
FGFR3 signaling, but a dominant negative form of PLCgamma ( DN-PLCgamma ) remarkably
reduced STAT1 phosphorylation
Krejci et al., PloS one 2008
(Bone Diseases, Developmental) :
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant
role of
STAT1 in
FGFR3 signaling in cartilage ... In a cell-free kinase assay, only K650M and
K650E-FGFR3 caused activatory
STAT1 ( Y701 ) phosphorylation ... Similarly, in RCS chondrocytes, HeLa, and 293T cellular environments, only K650M and
K650E-FGFR3 caused strong
STAT1 activation
Su et al., Nature 1997
(Thanatophoric Dysplasia) :
Activation of
Stat1 by mutant
fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism ... Furthermore, expression of TDII
FGFR3 induced nuclear translocation of
Stat1 , expression of the cell-cycle inhibitor p21 ( WAF1/CIP1 ), and growth arrest of the cell