Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — STAT1

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 2001 : Constitutively active forms of PI3K or Akt activate and their dominant negative derivatives inhibit STAT1-driven transactivation in response to IFN gamma
Molnarfi et al., J Immunol 2005 : Although both inhibitors of PI3K and MEK1 diminished the Ser ( 727 ) phosphorylation of STAT1 induced by IFN-beta, only Ly294002 inhibited sIL-1Ra production
Rahimi et al., J Immunol 2005 : Taken together, these results suggest that IL-10 induced CD14 up-regulation in human monocytic cells may be mediated by STAT-1 activation through the activation of PI3K either alone or in concert with the ERK MAPK
Rosner et al., Am J Pathol 2006 (Atherosclerosis) : IFN-gamma also stimulated Akt activity, and both Fas trafficking and Stat1 activation were inhibited by blocking PI3K , Akt, or Jak-2
Kanda et al., Eur J Immunol 2007 : Inhibitors of PI3 K , p38 MAPK, and MEK suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB, STAT1 , and IRF-1 activities
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models
Blank et al., Exp Cell Res 2013 : In conclusion, we herein demonstrated that STAT1 serine phosphorylation is mediated by the sequential activation of PI3K , PKCd and p38 MAPK